PL EN


Preferences help
enabled [disable] Abstract
Number of results
2013 | 18 | 18 | 187-191
Article title

STUDIES ON ADSORPTION CHlORAMFENICOL ON CHITOSANS IN PHARMACEUTICAL “IN VITRO” MODEL

Content
Title variants
Languages of publication
EN
Abstracts
EN
In clinical practice in the treatment of obesity, uses several natural macromolecular compounds, whose functioning is based on supporting the weight loss.
In use of dietary supplements containing chitosan, sometimes reaches the illness and in the treatment, which the other therapeutic agents are chemotherapeutic drugs.
The aim of our study was to determine the binding capacity of chloramphenicol chemotherapeutic depending on variable factors physico-chemical properties, present in the intestinal tract model of chitosans present in the drugs.
The phenomenon of adsorption of chloramphenicol was examined by a dynamic model simulating the conditions of the pharmaceutical in vitro. the amount of adsorbed chemotherapy. The obtained results show that chloramphenicol is adsorbed by chitosans at pH ranges used, and the binding capacity depends on the pH of the environment and the viscosity and concentration of the chemotherapeutic agent as well as the type of chitosan and the additional substances present in the gastrointestinal tract. The average size of the adsorption system chemotherapeutic chitosan-nutrients depending on the pH of the medium ranged from 22.3 to 100.0%. Maximum number of adsorption points above pH 7 (chitosan precipitated polymer forming the emulsion-gel system).
Keywords
Publisher

Year
Volume
18
Issue
18
Pages
187-191
Physical description
Contributors
author
  • Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw, jan.meler@am.wroc.pl
  • Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw
  • Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw
author
  • Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw
References
  • 1. A.C. Ford, S.V. Kane, K.J. Khan, Jean-Paul Achkar, N. J. Talley, J.K. Marshall and P. Moayyedi. Efficacy of 5-Aminosalicylates in Crohn's Disease: Systematic Review and Meta-Analysis. Am J Gastroenterol 2011; 106:617–629
  • 2. J. Meler, J. Pluta. The effect of auxiliary substances the activity of lipase pancreatic biopharmaceutical patternelof digestive tract. In: Progress of Chemistry and Application of Chitin and its Derivatives. Vol. X (ed.: H. Struszczyk), Polish Chitin Society, Łódź, pp. 131-137, 2004
  • 3. B. Grimling, J. Meler, J. Pluta.: Study of interaction of gastrointestinal agents in the presence of cytoprotective drug including bismuth W: Pierwiastki, środowisko i życie człowieka ; pod red. Kazimierza Pasternaka; Lublin : Polskie Towarzystwo Magnezologiczne, 2009; s.65-74
  • 4. J. Meler, B. Grimling, J. Pluta.: Investigation on adsorption of fatty and bile acids in the presence of dietary supplements containing chromium J.Elementol. 2010 Vol.15 no.1; s.141-147
  • 5. J. Meler.: Influence of different change on bioavailability of medicine chitosans antiphlogistic drugs Progress on Chemistry and Application of Chitin and Its Derivatives 2008 Vol.13; s.81-88
  • 6. J. Meler.: The effect of physicochemical factors on absorption properties of certain spasmolytics in the presence of dietary supplements containing chitosan Progress on Chemistry and Application of Chitin and Its Derivatives 2009 Vol.14; s.133-1435.
  • 7. U, Filipkowska, E. Klimiuk, , S. Grabowski,E , Siedlecka, . Adsorption of reactive dyes by modified chitin from aqueous solutions Pol. J. Environ. Stud., pp315- 323, 11,
  • 8. J. Meler.: The effect of physicochemical factors on absorption properties of certain spasmolytics in the presence of dietary supplements containing chitosan Progress on Chemistry and Application of Chitin and Its Derivatives 2009 Vol.14; s.133-1435.
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-15841008-3bc9-421d-b911-af69fe6ac841
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.