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2015 | 42 | 2 | 145-168
Article title

Znaczenie receptora estrogenów oddziałującego z białkami G w fizjologii i patofizjologii

Title variants
Involvement of G-protein Coupled Estrogen Receptor in physiology and physiopathology
Languages of publication
Estrogens, without doubt, play a pivotal role in the regulation of both physiological and pathological processes. A plethora of intercellular signaling pathways are regulated by estrogens on both genomic, and non–genomic pathways via canonical ERα and ERβ receptors. Studies published in recent years showed that not all biological effects of estrogens can be attributed to the classical model of estrogen signaling. Aside canonical ERα and ERβ receptors a G–protein coupled estrogen receptor plays its role in estrogen mediated regulation of various tissues and organs. Ubiquitous presence of G–protein coupled estrogen receptor in different tissues, as well as observed de–regulation of its expression in multiple pathologies suggest an important role of this receptor in functioning of cells, tissues and organisms. Activation/deactivation of GPER estrogen receptor takes place during the metabolism of carbohydrates, lipids and immunological response, it is involved in a number of events from reproductive, cardiovascular, neurological and skeletal systems.
Estrogeny, bez wątpienia, odgrywają istotną rolę w regulacji procesów fizjologicznych i patofizjologicznych. Za pośrednictwem kanonicznych recepto– rów estrogenów ERα i ERβ hormony te modulują wiele ścieżek sygnałowych w komórce zarówno na drodze genomowej, jak i niegenomowej. Wyniki badań ostatnich lat ujawniają, że nie wszystkie biologiczne efekty estrogenów wynikają z ich klasycznego modelu działania. Obok kanonicznych receptorów ERα i ERβ w estrogenozależnej regulacji funkcjonowania wielu tkanek i narządów pośred– niczy receptor estrogenów oddziałujący z białkami G. Powszechne występowa– nie receptora estrogenów oddziałującego z białkami G w różnych tkankach, jak i obserwowana deregulacja jego ekspresji w określonych patologiach pozwala domniemywać o istotnej roli tego receptora w funkcjonowaniu komórek, tkanek i organizmów. Aktywacja/dezaktywacja receptora estrogenów GPER ma miejsce podczas metabolizmu węglowodanów i lipidów czy odpowiedzi immunologicznej, zaangażowana jest w wiele zdarzeń ze strony układu rozrodczego, sercowo– naczyniowego, nerwowego oraz kostnego.

Physical description
  • Katedra Cytobiochemii, Uniwersytet Łódzki
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