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2015 | 42 | 2 | 145-168
Article title

Znaczenie receptora estrogenów oddziałującego z białkami G w fizjologii i patofizjologii

Content
Title variants
EN
Involvement of G-protein Coupled Estrogen Receptor in physiology and physiopathology
Languages of publication
PL
Abstracts
EN
Estrogens, without doubt, play a pivotal role in the regulation of both physiological and pathological processes. A plethora of intercellular signaling pathways are regulated by estrogens on both genomic, and non–genomic pathways via canonical ERα and ERβ receptors. Studies published in recent years showed that not all biological effects of estrogens can be attributed to the classical model of estrogen signaling. Aside canonical ERα and ERβ receptors a G–protein coupled estrogen receptor plays its role in estrogen mediated regulation of various tissues and organs. Ubiquitous presence of G–protein coupled estrogen receptor in different tissues, as well as observed de–regulation of its expression in multiple pathologies suggest an important role of this receptor in functioning of cells, tissues and organisms. Activation/deactivation of GPER estrogen receptor takes place during the metabolism of carbohydrates, lipids and immunological response, it is involved in a number of events from reproductive, cardiovascular, neurological and skeletal systems.
PL
Estrogeny, bez wątpienia, odgrywają istotną rolę w regulacji procesów fizjologicznych i patofizjologicznych. Za pośrednictwem kanonicznych recepto– rów estrogenów ERα i ERβ hormony te modulują wiele ścieżek sygnałowych w komórce zarówno na drodze genomowej, jak i niegenomowej. Wyniki badań ostatnich lat ujawniają, że nie wszystkie biologiczne efekty estrogenów wynikają z ich klasycznego modelu działania. Obok kanonicznych receptorów ERα i ERβ w estrogenozależnej regulacji funkcjonowania wielu tkanek i narządów pośred– niczy receptor estrogenów oddziałujący z białkami G. Powszechne występowa– nie receptora estrogenów oddziałującego z białkami G w różnych tkankach, jak i obserwowana deregulacja jego ekspresji w określonych patologiach pozwala domniemywać o istotnej roli tego receptora w funkcjonowaniu komórek, tkanek i organizmów. Aktywacja/dezaktywacja receptora estrogenów GPER ma miejsce podczas metabolizmu węglowodanów i lipidów czy odpowiedzi immunologicznej, zaangażowana jest w wiele zdarzeń ze strony układu rozrodczego, sercowo– naczyniowego, nerwowego oraz kostnego.
Discipline
Publisher

Year
Volume
42
Issue
2
Pages
145-168
Physical description
Contributors
  • Katedra Cytobiochemii, Uniwersytet Łódzki
References
  • Cygankiewicz AI, Jacenik D, Krajewska WM. Receptor GPER – nowy gracz w sygnalizacji estrogenowej. Postępy Biochem. 2015; 61: 52–60.
  • Prossnitz ER, Oprea TI, Sklar LA, Arterburn JB. The ins and outs of GPR30: a transmembrane estrogen receptor. J Steroid Biochem Mol Biol. 2008; 109: 350–353.
  • Prossnitz ER, Barton M.Estrogen biology: new insights into GPER function and clinical opportunities. Mol Cell Endocrinol. 2014; 389: 71–83.
  • Brown LM, Clegg DJ. Central effects of estradiol in the regulation of food intake, body weight, and adiposity. J Steroid Biochem Mol Biol. 2010; 122: 65–73.
  • Balhuizen A, Kumar R, Amisten S, Lundquist I, Salehi A. Activation of G protein–coupled receptor 30 modulates hormone secretion and counteracts cytokine–induced apoptosis in pancreatic islets of female mice. Mol Cell Endocrinol. 2010; 320: 16–24.
  • Mårtensson UEA, Salehi SA, Windahl S, Gomez MF, Sward K, Daszkiewicz–Nilsson J i wsp. Deletion of the G protein–coupled receptor 30 impairs glucose tolerance, reduces bone growth, increases blood pressure, and eliminates estradiol–stimulated insulin release in female mice. Endocrinol. 2009; 150: 687–698.
  • Sharma G, Hu C, Brigman JL, Zhu G, Hathaway HJ, Prossnitz ER. GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state. Endocrinol. 2013; 154: 4136–4145.
  • Davis KE, Carstens EJ, Irani BG, Gent LM, Hahner LM, Clegg DJ. Sexually dimorphic role of G protein–coupled receptor (GPER) in modulating energy homeostasis. Horm Behav. 2014; 66: 196–207.
  • Zhu P, Yuen JML, Sham KWY, Cheng CHK. GPER mediates the inhibitory actions of estrogen on adipogenesis in 3T3–L1 cells trough perturbation of mitotic clonal expansion. Gen Comp Endocrinol. 2013; 193: 19–26.
  • Wang C, Dehghani B, Magrisso IJ, Rick EA, Bonhomme E, Cody DB i wsp. GPR30 contributes to estrogen–induced thymic atrophy. Mol Endocrinol. 2008; 22: 636–648.
  • Brunsing RL, Prossnitz ER. Induction of interleukin–10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G–1. Immunology. 2011; 134: 93–106.
  • Bodhankar S, Vendenbark AA, Offner H. Oestrogen treatment of experimental autoimmune encephalomyelitis requires 17β–oestradiol–receptor–positive B cells that up–regulate PD–1 on CD4+ Foxp3+ regulatory T cells. Immunology. 2012; 137: 282–293.
  • Tamaki M, Konno Y, Kobayashi Y, Takeda M, Itoga M, Moritoki Y i wsp. Expression and functional roles of G–protein–coupled estrogen receptor (GPER) in human eosinophils. Immunol Lett. 2014; 160: 72–78.
  • Thomas P. Rapid steroid hormone actions initiated at the cell surface and the receptors that mediate them with an emphasis on recent progress in fish model. Gen Comp Endocrinol. 2012; 175: 367–383.
  • Pang Y, Thomas P. Role of G protein–coupled estrogen receptor 1, GPER, in inhibition of oocyte maturation by endogenous estrogens in Zebrafish. Dev Biol. 2010; 342: 194–206.
  • Peyton C, Thomas P. Involvement of epidermal growth factor receptor signaling in estrogen inhibition of oocyte maturation mediated through the G protein–coupled estrogen receptor (Gper) in Zebrafish (Danio rerio). Biol Reprod. 2011; 85: 42–50.
  • Li YR, Ren CE, Zhang Q, Li JC, Chian RC. Expression of G protein coupled estrogen receptor (GPER) on membrane of mouse oocytes during maturation. J Assist Reprod Genet. 2013; 30: 227–232.
  • Ge C, Yu M, Zhang C. G Protein–coupled receptor 30 mediates estrogen–induced proliferation of primordial germ cells via EGFR/Akt/β–catenin signaling pathway. Endocrinol. 2012; 153: 3504–3516.
  • Chimento A, Sirianni R, Delalande C, Silandre D, Bois C, Ando S i wsp. 17β–estradiol activates rapid signaling pathways involved in rat pachytene spermatocytes apoptosis through GPR30 and ERα. Mol Cell Endocrinol. 2010; 320: 136–144.
  • Khalil RA. Estrogen, vascular estrogen receptor and hormone therapy in post–menopausal vascular disease. Biochem Pharmacol. 2013; 86: 1627–1642.
  • Lindsey SH, Liu L, Chappell MC. Vasodilation by GPER in mesenteric arteries involves both endothelial nitric oxide and smooth muscle cAMP signaling. Steroids. 2013; 81: 99–102.
  • De Francesco EM, Angelone T, Pasqua T, Pupo M, Cerra MC, Maggiolini M. GPER mediates cardiotropic effects in spontaneously hypertensive rat hearts. PLoS ONE. 2013; 8:e69322.
  • Bopassa JC, Eghbali M, Toro L, Stefani E. A novel estrogen receptor GPER inhibits mitochondria permeability transition pore opening and protects the heart against ischemia–reperfusion injury. Am J Physiol Heart Circ Physiol. 2010; 298: 16–23.
  • Wang H, Jessup JA, Lin MS, Chagas C, Lindsey SH, Groban L. Activation of GPR30 attenuates diastolic dysfunction and left ventricle remodeling in oophorectomized mRen2.Lewis rats. Cardiovasc Res. 2012; 94: 96–104.
  • Chakrabarti S, Davidge ST. G–Protein Coupled Receptor 30 (GPR30): A novel regulator of endothelial inflammation. PLoS ONE. 2012; 7:e52357.
  • Ruiz–Palermo I, Hernando M, Garcia–Segura LM, Arevalo MA. G protein–coupled estrogen receptor is required for the neuritogenic mechanism of 17β–estradiol in developing hippocampal neurons. Mol Cell Endocrinol. 2013; 372: 105–115.
  • Bourque M, Morissette M, Di Paolo T. Raloxifen activates GPER1/Akt signaling to protect dopamine neurons in MPTP mice. Neurobiol Aging. 2014; 35: 2347–2356.
  • Kosaka Y, Quillinan N, Bond CT, Traystman RJ, Hurn PD, Herson PS. GPER1/GPR30 activation improves neuronal survival following global cerebral ischemia induced by cardiac arrest in mice. Transl Stroke Res. 2012; 3: 500–507.
  • Hammond R, Nelson D, Kline E, Gibbs RB. Chronic treatment with a GPR30 antagonist impairs acquisition of a spatial learning task in young rats. Horm Behav. 2012; 62: 367–374.
  • Tian Z, Wang Y, Zhang N, Guo Y, Feng B, Liu SL i wsp. Estrogen receptor GPR30 exerts anxiolytic effects by maintaining the balance between GABAergic and glutamatergic transmission in the basolateral amygdala of ovariectomized mice after stress. Psychoneuroendocrinology. 2013; 38: 2218–2233.
  • Heino TJ, Chagin AS, Savendahl L. The novel estrogen receptor G protein–coupled receptor 30 is expressed in human bone. J Endocrinol. 2008; 197: R1–6.
  • Foord SM, Bonner TI, Neubig RR, Rosser EM, Pin JP, Devenport AP i wsp. International Union of Pharmacology. XLVI. G Protein–coupled receptor list. Pharmacol Rev. 2005; 57: 279–288.
  • Ren J, Wu JH. 17β–estradiol rapidly activates calcium release from intercellular stores via the GPR30 pathway and MAPK phosphorylation in osteocyte–like MLO–Y4 cells. Calcif Tissue Int. 2012; 90: 411–419.
Document Type
paper
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-13cc7a97-c2b8-40e8-bf3d-5a888528c849
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