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2017 | 7 | 3 | 109-115
Article title

Changes in the pathomorphological diagnosis of gastrointestinal neuroendocrine neoplasms in 2017

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Abstracts
EN
The following changes were introduced in 2017 WHO and TnM classifications: 1. a new group of well-differentiated neuroendocrine tumors with the proliferation index of more than 20% and mitotic count of 20 per 10 hpf (NET G3), formerly classified under neuroendocrine carcinomas (NEC G3) 2. the division of poorly differentiated neuroendocrine tumors (PD NET) with the Ki-67 index of more than 20% into two groups in terms of the degree of differentiation and prognosis: NET G3 and NEC. 3. the replacement of MANEC with MINEN within the mixed group 4. the verification of histological grading (G) criteria 5. new TNM staging criteria, based on ENETS guidelines.
Discipline
Publisher

Journal
Year
Volume
7
Issue
3
Pages
109-115
Physical description
Contributors
  • 1. Department of Pathomorphology, Central Clinical Hospital of the Ministry of Interior and Administration in Warsaw. 2. Department of Pathology, Faculty of Medicine and Health Sciences, Jan Kochanowski University in Kielce, anna.guttmejer@gmail.com
References
  • 1. Rindi G, de Herder WW, O’Toole D et al. Consensus guidelines for the management of patients with digestive neuroendocrine tumors: why such guidelines and how we went about it. Neuroendocrinology 2006; 84(3): 155-157. DOI: 101159/000098006.
  • 2. Rindi G, de Herder WW, O’Toole D et al. Consensus guidelines for the management of patients with digestive neuroendocrine tumors: the second event and some final considerations. Neuroendocrinology 2008; 87(1): 5-7. DOI: 101159/000109975.
  • 3. Oberg K, Akerström G, Rindi G et al. ESMO Guidelines Working Group Neuroendocrine gastroenteropancreatic tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010; 21(supl 5): v223-v227. DOI: 101093/annonc/mdq192.
  • 4. Kvols LK, Brendtro KL; North American Neuroendocrine Tumor Society (NANETS). The North American Neuroendocrine Tumor Society (NANETS) Guidelines: mission, goals, and process. Pancreas 2010; 39(6): 705-706. DOI: 101097/MPA0b013e3181eb7451.
  • 5. Kos-Kudła B, Blicharz-Dorniak J, Handkiewicz-Junak D et al. Consensus Conference, Polish Network of Neuroendocrine Tumours Diagnostic and therapeutic guidelines for gastro-entero-pancreatic neuroendocrine neoplasms (recommended by the Polish Network of Neuroendocrine Tumours). Endokrynol Pol 2013; 64(6): 418-443. DOI: 105603/EP20130028.
  • 6. Kos-Kudła B, Blicharz-Dorniak J, Strzelczyk J et al. Diagnostic and therapeutic guidelines for gastro-entero-pancreatic neuroendocrine neoplasms (recommended by the Polish Network of Neuroendocrine Tumours). Endokrynol Pol 2017; 68 (2): 79-110. DOI: 105603/EP20170015.
  • 7. Lipiński M, Rydzewska G, Fołtyn W et al. Gastroduodenal neuroendocrine neoplasms, including gastrinoma – management guidelines (recommended by the Polish Network of Neuroendocrine Tumours). Endokrynol Pol 2017; 68(2): 138-153. DOI: 105603/EP20170016.
  • 8. Starzyńska T, Londzin-Olesik M, Bałdys-Waligórska A et al. Colorectal neuroendocrine neoplasms – management guidelines (recommended by the Polish Network of Neuroendocrine Tumours). Endokrynol Pol 2017; 68(2): 250-260. DOI: 105603/EP20170019.
  • 9. Kos-Kudła B, Rosiek V, Borowska M et al. Pancreatic neuroendocrine neoplasms — management guidelines (recommended by the Polish Network of Neuroendocrine Tumours). Endokrynol Pol 2017; 68(2): 169-179. DOI: 105603/EP20170017.
  • 10. Bednarczuk T, Bolanowski M, Zemczak A et al. Neuroendocrine neoplasms of the small intestine and appendix — management guidelines (recommended by the Polish Network of Neuroendocrine Tumours). Endokrynol Pol 2017; 68(2): 223-236. DOI: 105603/EP20170018.
  • 11. Franko J, Feng W, Yip L et al. Non-functional neuroendcrine carcinoma of the pancreas: incidence, tumor biology, and outcomes in 2, 158 patients. J Gastrointest Surg 2010; 14: 541-548.
  • 12. Kolasińska-Ćwikła A. The mTOR signalling pathways in the pathogenesis and treatment of neuroendocrine tumours. Oncoreview 2016; 1(6): 37-42. DOI: 105604/208286911198520.
  • 13. Solcia E, Kloppel G, Sobin LH. Histological Typing of Endocrine Tumours, 2nd edn. World Health Organization International Histological Classification of Tumours, Springer, Berlin 2000.
  • 14. Kloppel G, Perren A, Heitz PU. The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification. Ann NY Acad Sci 2004; 1014: 13-27. DOI:101196/annals1294002.
  • 15. Rindi G, Capella C et al. Nomenclature and classification of digestive neuroendocrine tumors. In: Bosman FT, Carneiro F, Hruban RH et al. (ed.). World Health Organization Classification of Tumours, Pathology and Genetics of Tumours of the Digestive System IARC Press, Lyon 2010: 13-14.
  • 16. Nasierowska-Guttmejer A. Nowa klasyfikacja NET. OncoReview 2011; 1: 46-50.
  • 17. Niederle MB, Hacki M, Kaserer K et al. Gastroenteropancreatic neurendocrine tumours: the current incidence and staging based on the WHO and European Neuroendocrine Tumour Society classification: an analysis based on prospectively collected parameters. Endocrine-Related Cancer 2010; 17: 909-918.
  • 18. Rindi G, Klöppel G, Alhman H et al; all other Frascati Consensus Conference participants. European Neuroendocrine Tumor Society (ENETS): TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system. Virchows Arch 2006; 449(4): 395-401. DOI: 101007/ s00428-006-0250-1.
  • 19. Rindi G, Kloppel G, Couvelard A et al. TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system. Virchows Arch 2007; 451(4): 757-762. DOI:10 1007/s00428-007-0452-1.
  • 20. Klöppel G, Rindi G, Perren A et al. The ENETS and AJCC/UICC TNM classifications of the neuroendocrine tumors of the gastrointestinal tract and the pancreas: a statement. Virchows Arch 2010; 456(6): 595-597. DOI: 101007/s00428-010-0924-6.
  • 21. Kloppel G, Couvelard A, Hruban RH et al. Neoplasm of the neuroendocrine pancreas. In: Lloyd RV, Osamura R, Kloppel G, Rosai J. WHO Classification of Tumours of Endocrine Organs IARC Press, Lyon 2017: 210-221.
  • 22. Woltering EA, Bergsland EK, Beyer DT et al. Neuroendocrine Tumors of the Stomach American Joint Committee on Cancer 2017. In: Amin MB et al. (ed.). AJCC Cancer Staging Manual Eight Edition Springer, 2017: 351-359. DOI 101007/978-3-319-40618-3_30.
  • 23. Bergsland E, Woltering E, Rindi G et al. Neuroendocrine Tumors of the Duodenum and Ampulla of Vater. AJCC Cancer Staging Manual 2016: 361- 373. DOI: 101007/978-3-319-40618-3_30.
  • 24. Woltering EA, Bergsland EK, Beyer DT et al. Neuroendocrine Tumors of the Jejunum and Ileum American Joint Committee on Cancer 2017. In: Amin MB et al. (ed.). AJCC Cancer Staging Manual Eight Edition Springer, 2017: 375-387. DOI 101007/978-3-319-40618-3_30.
  • 25. Woltering EA, Bergsland EK, Beyer DT et al. Neuroendocrine Tumors of the Appendix American Joint Committee on Cancer 2017. In: Amin MB et al. (ed.). AJCC Cancer Staging Manual Eight Edition Springer, 2017: 389-394. DOI 101007/978-3-319-40618-3_30.
  • 26. Shi Ch, Woltering E, Deyer DT et al. Neuroendocrine Tumors of the Colon and Rectum American Joint Committee on Cancer 2017. In: Amin MB et al. (ed.). AJCC Cancer Staging Manual Eight Edition Springer, 2017: 395-406. DOI 101007/978-3-319-40618-3_30.
  • 27. Brierley JD, Gospodarowicz MK, Wittekind C et al. (ed.). UICC TNM Classification of Malignant Tumours Eight Edition Wiley Blackwell, 2017.
  • 28. Basturk O, Tang L, Hruban RH et al. Poorly differentiated neuroen¬docrine carcinomas of the pancreas: a clinicopathologic analysis of 44 cases Am J Surg Pathol 2014; 38(4): 437-447
  • 29. Basturk O, Yang Z, Tang LH et al. The high-grade (WHO G3) pancreatic neuroendocrine tumor category is morphologically and biologically heterogenous and includes both well differentiated and poorly differentiated neoplasms. Am J Surg Pathol 2015; 39(5): 683-690.
  • 30. Heetfeld M, Chougnet CN, Olsen IH et al.; other Knowledge Network members: Characteristics and treatment of patients with G3 gastroenteropancreatic neuroendocrine neoplasms. Endocr Relat Cancer 2015; 22(4): 657-664. DOI: 101530/ERC-15-0119.
  • 31. Crippa S, Partelli S, Belfiori G et al. Management of neuroendocrine carcinomas of the pancreas (WHO G3): A tailored approach between proliferation and morphology. World J Gastroenterol 2016; 22(45): 9944-9953. DOI: 103748/wjgv22i459944.
  • 32. Tang LH, Basturk O, SUE JJ et al. A Practical Approach to the Classification of WHO Grade 3 (G3) Well-differentiated Neuroendocrine Tumor (WDNET) and Poorly Differentiated Neuroendocrine Carcinoma (PD-NEC) of the Pancreas. Am J Surg Pathol 2016; 40: 1192-1202.
  • 33. Milione M, Maisonneuve P, Spada F et al. The Clinicopathologic Heterogeneity of Grade 3 Gastroenteropancreatic Neuroendocrine Neoplasms: Morphological Differentiation and Proliferation Identify Different Prognostic Categories. Neuroendocrinology 2017; 104(1): 85-93. DOI: 101159/000445165.
  • 34. Konukiewitz B, Schlitter M, Jesinghaus M. Somatostatin receptor expression related to TP53 and RB1 alterations in pancreatic and extrapancreatic neuroendocrine neoplasms with a Ki67-index above 20%. Modern Pathology 2016; 30: 587-598. DOI:101038/modpathol2016217.
  • 35. Reid MD, Bagci P, Ohike N et al. Calculation of the Ki67 index in the pancreatic neuroendocrine tumors: a comparative analysis of four counting methodologies. Mod Path 2015; 28: 686-694.
  • 36. Bergsland EK, Woltering EA, Rindi G et al. Neuroendocrine Tumors of the Pancreas American Joint Committee on Cancer 2017. In: Amin MB et al. (ed.). AJCC Cancer Staging Manual Eight Edition Springer, 2017: 407-419. DOI 101007/978-3-319-40618-3_30.
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-113f3579-be6a-4cef-85ff-a8e30dd0e983
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