Synthesis and spectral analysis of 2-alkyl/aryl amino derivatives of pyrimidine-5-carbonitrile

• Authors: Bhavana Godhaniya , Jalpa Vadgama , Pragna Thanki , J. J. Modha
• Languages of publication: EN

Abstracts

EN

A new series of 2-aryl/alkyl amino pyrimidines derivatives has been undertaken by the condensation of 1-ethyl-2-(ethylthio)-1,6-dihydro-6-oxo-4-phenylpyrimidine-5-carbonitrile with different alkyl/aryl amines. The electrophilic substitution reaction taking place between main moiety 1,2,3,4-tetrahydro-4-oxo-6-phenyl-2-thioxopyrimidine-5-carbonitrile and ethyl iodide to give dialkylated compound which is followed by nucleophilic substitution reaction with amine to give different aryl/alkyl amino pyrimidine derivatives.

Keywords

EN

2-aryl/alkyl amino; S & N alkylation; pyrimidines-5-carbonitrile

Discipline

• CHEMISTRY: CHEMISTRY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World Scientific News
• Year: 2022
• Volume: 168
• Pages: 30-44

Contributors

author

Bhavana Godhaniya

• Department of Chemistry, M. D. Science College, Porbandar – 360575, Gujarat, India

author

Jalpa Vadgama

• Department of Chemistry, M. D. Science College, Porbandar – 360575, Gujarat, India

author

Pragna Thanki

• Department of Chemistry, M. D. Science College, Porbandar – 360575, Gujarat, India

author

J. J. Modha

• Department of Chemistry, M. D. Science College, Porbandar – 360575, Gujarat, India

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• Document Type: article