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2018 | 108 | 215-223
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The effect of prolonged hanging test to grip strength, changes in muscle mass and imunoekspresi IGF-1r in bicep muscle of mice (Swiss Webster)

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Resistance training increases strength and stamina without enlarging muscle. Jaras ifg1 responsible for the proliferation and differentiation of muscle tissue in response to the exercise. Post-allocation of adaptation 36 research subjects were randomly allocated to the control group and the test. The purpose of this study to determine the effect of prolonged hanging test of grip strength, muscle mass changes and IGF-1r imunoekspresi the bicep muscles of mice. The uniqueness differences in physiological mechanisms increase the strength after resistance exercise through changes in the dynamics of unknown IGF1 receptors , so this time we did the study increased expression of IGF1 receptors (Igf1r) after resistance exercise, using new method is prolonged hanging test. Grip strength, muscle mass and score imunoekspresi igf1r in bicep muscles will be tested in the mice model (Swiss webster) using pre and posttest design. Examination of grip strength, muscle mass, muscle fiber cross-sectional diameter and imunoekspresi IGF-1r have done at day 28 in the Laboratory of Pathology in Dr. Hasan Sadikin Hospital, Bandung. Our results showed there were effect of prolonged hanging test to grip strength in the final test on mice and igf1r Imunoekspresi on mice. This research concluded that resistance exercise using hanging prolonged test increases grip strength and receptor expression igf1r without increasing muscle mass or muscle fiber cross-sectional diameter.
Physical description
  • Graduate School of Biomedical Sciences Master Program, Faculty of Medicene, Universitas Padjadjaran Jalan Raya Sumedang-Jatinangor KM 22 Sumedang, Indonesia
  • Department of Pathology Anatomy Faculty of Medicine, Universitas Padjadjaran, Jalan Raya Sumedang-Jatinangor KM 22 Sumedang, Indonesia
  • Department of Orthopaedy dan Traumatology Faculty of Medicine, Universitas Padjadjaran, Jalan Raya Sumedang-Jatinangor KM 22 Sumedang, Indonesia
  • Department of Physiology, Universitas Padjadjaran, Jalan Raya Sumedang-Jatinangor KM 22 Sumedang, Indonesia
  • Graduate School of Biomedical Sciences Master Program, Faculty of Medicene, Universitas Padjadjaran Jalan Raya Sumedang-Jatinangor KM 22 Sumedang, Indonesia
  • [1] Topp R., Fahlman M., Boardley D. Healthy aging: health promotion and disease prevention. Nurs Clin North Am. 2004 Jun; 39(2): 411-22.
  • [2] Kell R, Bell G, Quinney A. Musculoskeletal fitness, health outcomes and quality of life. Sport Med. 2017; 31(12): 863-873.
  • [3] Warburton D, Glendhill N, Quinney A. The effects of changes in musculoskeletal fitness on health. Can J Appl Physiol. 2016; 26(2): 161-216.
  • [4] Kraemer W, Adams K, Cafarelli E, Dudley G, Dooly C, Feigenbaum M. Progression models in resistance training for healthy adults. Med Sci Sport Exerc. 2018; 34(2): 364–80.
  • [5] Kraemer W, Ratamess N. Fundamentals of Resistance Training: Progression and Exercise Prescription. Medicine and Science in Sports and Exercise. 2017; P: 674-88.
  • [6] Close G, Kayani A, Vasilaki A, McArdle A. Skeletal muscle damage with exercise and aging. Sports Medicine. 2014; P: 413-27.
  • [7] Deschenes M, Kraemer W. Performance and physiologic adaptations to resistance training. Am J Phys Med Rehabil. 2015; 81(11 Suppl): S3–16.
  • [8] Aagaard P. Making muscles “stronger”: Exercise, nutrition, drugs. Journal of Musculoskeletal Neuronal Interactions. 2016; P: 165-74.
  • [9] Fry A. The role of resistance exercise intensity on muscle fibre adaptations. Sports Medicine and Science in Sports and Exercise. 2016; P: 663-79.
  • [10] Goldspink G. Gene expression in muscle in response to exercise. Journal of Muscle Research and Cell Motility. 2015; P: 121-6.
  • [11] Glass D. Signalling pathways that mediate skeletal muscle hypertrophy and atrophy. Nat Cell Biol. 2009; 5(2): 87-90.
  • [12] Pandini G, Frasca F, Mineo R, Sciacca L, Vigneri R, Belfiore A. Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J Biol Chem. 2017; 277(42): 39684–95.
  • [13] Philippou a, Halapas a, Maridaki M, Koutsilieris M. Type I insulin-like growth factor receptor signaling in skeletal muscle regeneration and hypertrophy. J Musculoskelet Neuronal Interact. 2016; 7(3): 208–218.
  • [14] Denley A, Cosgrove L, Booker G, Wallace J, Forbes B. Molecular interactions of the IGF system. Cytokine and Growth Factor Reviews. 2016; P: 421-439.
  • [15] Brisson B, Barton E. New modulators for IGF-I activity within IGF-I processing products. Front Endocrinol (Lausanne). 2017; 4(MAR): 1-6.
  • [16] Baudry A, Lamothe B, Bucchini D, Jami J, Montarras D, Pinset C. IGF-1receptor as an alternative receptor for metabolic signaling in insulin receptor-deficient muscle cells. FEBS Lett. 2016; 488(3): 174-8.
  • [17] Gallagher P, Touchberry C, Teson K, McCabe E, Tehel M, Wacker M. Effects of an acute bout of resistance exercise on fiber-type specific to GLUT4 and IGF-1R expression. Appl Physiol Nutr Metab. 2013; 38(5): 581-6.
  • [18] Carlson G, Carlson G. The use of four limb hanging tests to monitor muscle strength and condition over time Official reviewer. 2014; Id: 1-11.
  • [19] Klein S, Vykoukal J, Lechler P, Zeitler K, Gehmert S, Schreml S. Noninvasive in vivo assessment of muscle impairment in the mdx mouse model - A comparison of two common wire hanging methods with two different results. J Neurosci Methods. 2017; 203(2): 292-7.
  • [20] Federer W. Experimental Design, Theory and Aplication. New York: The MacMillan Company; 2009.
  • [21] Hall J, Guyton A. Textbook of Medical Physiology 2006, 1-1152 p.
  • [22] Murray R, Davis J, Sharkey BG. Harper’s Illustrated Biochemistry. Molecular Physiology and Sport Physiology for Coaches. Sport Physiology for Coaches. 2017; p. 38.
  • [23] TD D, N. Exercise : muscle and metabolic requirement. In Encyclopedia of Food Sciences & Nutrition. 2nd Edition ed: Academic Press; 2016.
  • [24] Benardot D. Advanced Sports nutrition. Champaign, IL. 2017.
  • [25] Willis L, Slentz C, Bateman L, Shields A, Piner L, Bales C, et al. Effects of aerobic and/or resistance training on body mass and fat mass in overweight or obese adults. Physiol. 2017; 113: 1831–37.
  • [26] Hafstad A, Lund J, Hadler-Olsen E, Höper A, Larsen T, Aasum E. Highand moderate-intensity training normalizes ventricular function and mechanoenergetics in mice with diet-induced obesity. Diabetes. 2013; 62: 2287–94.
  • [27] Thomas D, Bouchard C, Church T, Slentz C, Kraus W, Redman L, et al. Why do individuals not lose more weight from an exercise intervention at a defined dose? An energy balance analysis. Obes 2012; 13: 835–47.
  • [28] Yang H, Alnaqeeb M, Simpson H, Goldspink G, Changes in muscle fibre type, muscle mass and IGF-I gene expression in rabbit skeletal muscle subjected to stretch. J Anat. 1997 May; 190 (Pt 4): 613-622.
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