Wpływ używek na rozwój nowotworów ginekologicznych

• Authors: Anna Markowska , Joanna Kaysiewicz , Anna Makówka , Rafał Staszewski , Janina Markowska , Monika Pawłowska

Title variants

EN

Infl uence of recreational psychoactive substances on the development of gynecologic cancers

• Languages of publication: EN PL

Abstracts

EN

Tea and coffee, beverages most commonly consumed by people, contain flavonoids, which have an antioxidant effect. It has been proven that green tea consumption protects against both precancerous lesions and cervical cancer. Black tea consumption is associated with a reduced risk of ovarian and breast cancer development in postmenopausal women. Drinking coffee lowers the risk of type I endometrial cancer. The majority of studies on postmenopausal women with breast cancer show a protective role of coffee, which seems to be related to the state of hormonal receptors. Alcoholic beverages, on the other hand, are classified as class 1 carcinogens and their metabolism generates harmful free radicals. Alcohol is also associated with an increased risk of HPV infection, which is in turn causally responsible for the development of precancerous cervical lesions. In addition, alcohol increases the risk of recurrence of cervical cancer. In the case of endometrial cancer the views are rather divergent. Some studies suggest that beer and wine may reduce the risk of cancer, while other studies show that other alcoholic beverages consumed in greater quantities increase that risk. While the consumption of wine is believed to reduce the risk of development of endometrioid ovarian cancer, there is no proof of the same effect on other histopathological types of this disease. This phenomenon may be associated with the protective effect of resveratrol. Various types of alcohol, on the other hand, have been proven to be conducive to the development of breast cancer.

PL

Herbata i kawa – napoje bardzo często spożywane przez ludzi – zawierają flawonoidy, mające działanie antyoksydacyjne. Wykazano protekcyjny wpływ konsumpcji zielonej herbaty na rozwój zarówno stanów przedrakowych, jak i raka szyjki macicy. Picie czarnej herbaty wiąże się zaś ze spadkiem ryzyka wystąpienia raka jajnika i raka piersi u kobiet po menopauzie. Spożycie kawy obniża ryzyko rozwoju raka endometrium typu I. Większość badań wskazuje również na ochronne działanie kawy w odniesieniu do raka piersi u kobiet po menopauzie; jak się wydaje, zależy ono od stanu receptorów hormonalnych. Z kolei napoje alkoholowe, zaklasyfikowane jako karcynogeny klasy I, zawierają substancje o działaniu rakotwórczym, a w wyniku ich metabolizmu powstają szkodliwe wolne rodniki. Wykazano, że alkohol zwiększa ryzyko infekcji HPV, przyczynowo związanej z rozwojem stanów przedrakowych szyjki macicy, a także ryzyko nawrotu raka szyjki macicy. W przypadku raka endometrium uzyskiwano rozbieżne wyniki – wydaje się, że piwo i wino mogą obniżyć ryzyko, jednak inne napoje alkoholowe spożywane w większej ilości je zwiększają. Picie wina wiąże się ze spadkiem ryzyka rozwoju endometrioidalnego raka jajnika, ale nie innych typów histologicznych tego nowotworu; może to być związane z protekcyjnym działaniem resweratrolu. Wykazano, że różne rodzaje alkoholu są niekorzystne w kontekście rozwoju raka piersi.

Keywords

EN

alcohol; alkohol; breast cancer; cervical cancer; coffee; endometrial cancer; herbata; kawa; ovarian cancer; rak endometrium; rak jajnika; rak piersi; rak szyjki macicy; tea

Discipline

• MEDICINE: MEDICINE

• Publisher: Medical Communications
• Journal: Current Gynecologic Oncology
• Year: 2016
• Volume: 14
• Issue: 2
• Pages: 109–116

Contributors

author

Anna Markowska

• Klinika Perinatologii i Chorób Kobiecych, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Poznań, Polska. Kierownik Kliniki: prof. dr hab. n. med. Krzysztof Drews

author

Joanna Kaysiewicz

• Roche Polska, Warszawa, Polska

author

Anna Makówka

• Roche Polska, Warszawa, Polska

author

Rafał Staszewski

• Szpital Kliniczny Przemienienia Pańskiego, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Poznań, Polska

author

Janina Markowska

• Klinika Onkologii, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Poznań, Polska. Kierownik Kliniki: prof. dr hab. n. med. Rodryg Ramlau

author

Monika Pawłowska

• Oddział Ginekologii Onkologicznej, Szpital Kliniczny Przemienienia Pańskiego UM w Poznaniu, ul. Szamarzewskiego 82/84, 60-569 Poznań, tel.: [phone]

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• Document Type: review