PL EN


Preferences help
enabled [disable] Abstract
Number of results
2017 | 71 | 265-274
Article title

The role of suPAR in kidney diseases

Content
Title variants
PL
Rola suPAR w chorobach nerek
Languages of publication
EN PL
Abstracts
EN
Chronic kidney disease (CKD) is unquestionably a problem of social significance because it affects about 10% of the population. There is a search for biomarkers which could help select persons out of such a large group of patients with a high risk of disease progression and of its complications. The major cause of death in patients with end-stage renal disease are cardiovascular diseases. Accelerated atherosclerosis in this group of patients is associated with a chronic inflammatory state. The new biological marker of inflammation suPAR (soluble urokinase-type plasminogen activator receptor), is the focus of attention of the authors of this report. The relationship of suPAR with urinary tract infections and focal segmental glomerulosclerosis is also very interesting from the clinical perspective. The perception of suPAR as a blood circulating factor, inducing FSGS, throws new light on the pathomechanism of this medical condition, while unveiling promising therapeutic perspectives. A better understanding of the pathogenesis of the diseases discussed will help to reduce the unacceptably high mortality rate in patients with CKD. At present, common assaying of suPAR is not yet possible in the context of the above-mentioned issues. Nevertheless, studies are ongoing which may explain the still unclear issues concerning the relationship of the biomarker with the mentioned kidney diseases. Perhaps, follo-wing their results suPAR assays may in the near future become routine diagnostics means in selected kidney diseases.
PL
Przewlekła choroba nerek (PChN) to niewątpliwie problem o znaczeniu społecznym, dotyczy bowiem około 10% populacji. Poszukiwane są biomarkery, dzięki którym spośród tak dużej liczby pacjentów udałoby się wyselekcjonować osoby z dużym ryzykiem progresji choroby i jej powikłań. Główną przyczyną zgonów u pacjentów ze schyłkową niewydolnością nerek są choroby układu sercowo-naczyniowego. Przyspieszony rozwój miażdżycy w tej grupie chorych wiąże się z przewlekłym stanem zapalnym. Przedmiotem zainteresowania autorów pracy jest nowy biomarker stanu zapalnego suPAR (soluble urokinase-type plazminogen activator receptor – rozpuszczalna forma receptora aktywatora plazminogenu typu urokinazy). Z klinicznego punktu widzenia interesujący jest również związek suPAR z zakażeniami układu moczowego oraz ogniskowym segmentalnym stwardnieniem kłębuszków nerkowych (focal segmental glomerulosclerosis – FSGS). Identyfikacja suPAR, jako krążącego we krwi czynnika wywołującego FSGS, rzuca nowe światło na patomechanizm choroby i stwarza obiecujące możliwości lecznicze. Lepsze zrozumienie patogenezy omawianych schorzeń pomogłoby zredukować nieakceptowalnie wysoką śmiertelność pacjentów z PChN. Na dzień dzisiejszy nie można zlecać powszechnego oznaczania suPAR w kontekście omawianych zagadnień. Niemniej trwają badania, które pozwolą wyjaśnić niejasne kwestie dotyczące związku biomarkera z omawianymi schorzeniami nerek. Być może na podstawie ich wyników w najbliższych latach oznaczanie suPAR w wybranych chorobach nerek będzie rutynowe.
Discipline
Publisher

Year
Volume
71
Pages
265-274
Physical description
Contributors
  • Katedra Chorób Wewnętrznych, Diabetologii i Nefrologii, Wydział Lekarski z Oddziałem Lekarsko-Dentystycznym w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach, lacka@onet.pl
  • Katedra Chorób Wewnętrznych, Diabetologii i Nefrologii, Wydział Lekarski z Oddziałem Lekarsko-Dentystycznym w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach
  • Oddział Nefrologii, Wojewódzki Szpital Specjalistyczny nr 4 w Bytomiu
  • Katedra Chorób Wewnętrznych, Diabetologii i Nefrologii, Wydział Lekarski z Oddziałem Lekarsko-Dentystycznym w Zabrzu, Śląski Uniwersytet Medyczny w Katowicach
References
  • 1. Rutkowski B. Przewlekła choroba nerek – diagnostyka i leczenie. Via Medica, Gdańsk 2012: VII-VIII; s. 86–87.
  • 2. Rutkowski B., Lichodziejewska-Niemierko M., Grenda R., Czekalski S., Durlik M., Bautembach S. Raport o stanie leczenia nerkozastępczego w Polsce – 2009. Gdańsk 2012.
  • 3. Thuno M., Macho B., Eugen-Olsen J. suPAR: the molecular crystal ball. Dis. Markers 2009; 27(3): 157–172.
  • 4. Szczeklik A. Choroby wewnętrzne. Medycyna Praktyczna. Kraków 2006, s. 1394–1399; 1337–1340.
  • 5. Thielemann A., Kopczyński Z. Zaburzenia układu fibrynolitycznego u chorych na raka. Nowiny Lek. 2012; 81(2): 164–169.
  • 6. Xu L.B., Chi N., Shi W. Amiloride, a urokinase-type plasminogen activator receptor (uTPA) inhibitor, reduces proteinuria in podocytes. Genet. Mol. Res. 2015; 14(3): 9518–9529.
  • 7. Resnati M., Guttinger M., Valcamonica S., Sidenius N., Blasi F., Fazioli F. Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect. EMBO J. 1996; 15(7): 1572–1582.
  • 8. Wilhelm O.G., Wilhelm S., Escott G.M., Lutz V., Magdolen V., Schmitt M., Rifkin D.B., Wilson E.L., Graeff H., Brunner G. Cellular glyco-sylphosphatidylinositol-specific phospholipase D regulates urokinase receptor shedding and cell surface expression. J. Cell Physiol. 1999; 180(2): 225–235.
  • 9. Hoyer-Hansen G., Pessara U., Holm A. Pass J, Weidle U, Danø K, Behrendt N. Urokinase-catalysed cleavage of the urokinase receptor requires an intact glycolipid anchor. Biochem. J. 2001; 358(Pt3): 673–679.
  • 10. Wei C., El Hindi S., Li J. Fornoni A., Goes N., Sageshima J., Maiguel D., Karumanchi S.A., Yap H.K., Saleem M., Zhang Q., Nikolic B., Chaudhuri A., Daftarian P., Salido E., Torres A., Salifu M., Sarwal M.M., Schaefer F., Morath C., Schwenger V., Zeier M., Gupta V., Roth D., Rastaldi M.P., Burke G., Ruiz P., Reiser J. Circulating urokinase receptor as a causa of focal segmental glomerulosclerosis. Nat. Med. 2011; 17(8): 952–960.
  • 11. Florquin S., van den Berg J.G., Olszyna D.P. Claessen N., Opal S.M., Weening J.J., van der Poll T. Relase of urokinase plasminogen activator re-ceptor during urosepsis and ednotoxemia. Kidney Int. 2001; 59(6): 2054–2061.
  • 12. Gustafsson A., Ajeti V., Ljunggren L. Detection of suPAR in the saliva of healthy young adults: comparison with plasma levels. Biomark Insights 2011; 6: 119–125.
  • 13. Tzanakaki G., Paparoupa M., Kyprianou M., Barbouni A., Eugen-Olsen J., Kourea-Kremastinou J. Elevated soluble urokinase receptor values in CSF, age and bacterial meningitis infection are independent and additive risk factors of fatal outcome. Eur. J. Clin. Microbiol. Infect. Dis. 2012; 31(6): 1157–1162.
  • 14. Leandersson P., Kalapotharakos G., Henic E., Borgfeldt H., Petzold M., Høyer-Hansen G., Borgfeldt C. A Biomarker Panel Increases the Diagnostic Performance for Epithelial Ovarian Cancer Type I and II in Young Women. Anticancer Res. 2016; 36(3): 957–965.
  • 15. Shen J., Wang Q., Wang J. Su G.H., Wang J., Guo S.H., Liu Y.A., Wu Z., Liu R.F., Li X., Guo X.J., Cao J., Zhang Y.H., Wang Z.Y. Analysis of soluble urokinase plasminogen activator receptor in multiple myeloma for predicting prognosis. Oncol. Lett. 2015; 10(4): 2403–2409.
  • 16. Kasanq C., Kalluvya S., Majinge C., Kongola G., Mlewa M., Massawe I., Kabyemera R, Magambo K., Ulmer A., Klinker H., Gschmack E., Horn A., Koutsilieri E., Preiser W., Hofmann D., Hain J., Müller A., Dölken L., Weissbrich B., Rethwilm A, Stich A., Scheller C. Effects of Prednisolone on Disease Progression in Antiretroviral-Untreated HIV Infection: A 2-Year Randomized, Double-Blind Placebo-Controlled Clinical Trial. PLoS One 2016; 11(1): e0146678.
  • 17. Outinen T.K., Tervo L., Makela S., Huttunen R., Mäenpää N., Huhtala H., Vaheri A., Mustonen J., Aittoniemi J. Plasma levels of soluble urokinase-type plasminogen activator receptor associate with the clinical severity of acute Puumala hantavirus infection. PLoS One 2013; 8(8): e71335.
  • 18. Siahanidou T., Margeli A., Tsirogianni C., Charoni S., Giannaki M., Vavourakis E., Charisiadou A., Papassotiriou I. Clinical value of plasma soluble urokinase-type plasminogen activator receptor levels in term neonates with infection or sepsis: a prospective study. Mediators Inflamm. 2014; 2014: 375702.
  • 19. Backes Y., van der Sluijs K.F., Mackie D.P., Tacke F., Koch A., Tenhunen J.J., Schultz M.J. Usefulness of suPAR as a biological marker in patients with systemic inflammation or infection: a systemic review. Intensive Care Med. 2012; 38(9): 1418–1428.
  • 20. Koch A., Voigt S., Kruschinski C., Sanson E., Dückers H., Horn A., Yagmur E., Zimmermann H., Trautwein C., Tacke F. Circulating soluble urokinase plasminogen activator receptor is stably elevated during the first week of treatment in the intensive care unit and predicts mortality in critically ill patients. Crit. Care 2011; 15(1): R63.
  • 21. Eugen-Olsen J., Andersen O., Linneberg A., Ladelund S., Hansen T.W., Langkilde A., Petersen J., Pielak T., Møller L.N., Jeppesen J., Lyngbaek S., Fenger M., Olsen M.H., Hildebrandt P.R., Borch-Johnsen K., Jørgensen T., Haugaard S.B. Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population. J. Intern. Med. 2010; 268(3): 296–308.
  • 22. Wittenhagen P., Andersen J.B., Hansen A., Lindholm L., Rønne F., Theil J., Tvede M., Eugen-Olsen J. Plasma soluble urokinase plasminogen activator receptor in children with urinary tract infection. Biomark Insights. 2011; 6: 79–82.
  • 23. O’Shaughnessy M.M., Montez-Rath M.E., Lafayette R.A., Winkelmayer W.C. Patient characteristics and outcomes by GN subtype in ESRD. Clin. J. Am. Soc. Nephrol. 2015; 10(7): 1170–1178.
  • 24. Radha S., Afroz T., Prasad Ch.R. Sridhar G., Rajaram K.G., Reddy S. Focal segmental glomerulosclerosis in renal allografts: Is it possible to diagnose the etiology? Indian J. Nephrol. 2015; 25(2): 82–85.
  • 25. Couser W. Reccurent glomerulonephritis in the renal allograft: an update of selected areas. Exp. Clin. Transplant. 2005; 3(1): 283–288.
  • 26. Savin V.J., Sharma R., Sharma M., McCarthy E.T., Swan S.K., Ellis E., Lovell H., Warady B., Gunwar S., Chonko A.M., Artero M., Vincenti F. Circulating factor associated with increased glomerular permeability to albumin in recurrent focal segmental glomerulosclerosis. N. Engl. J. Med. 1996; 334(14): 878–883.
  • 27. Kashgary A., Sontrop J.M., Li L., Al-Jaishi A.A., Habibullah Z.N., Alsolaimani R., Clark W.F. The role of plasma exchange in treating post-transplant focal segmental glomerulosclerosis: A systematic review and meta-analysis of 77 case-reports and case-series. BMC Nephrol. 2016; 17(1): 104.
  • 28. Kemper M.J., Wolf G., Muller-Wiefel D.E. Transmission of glomerular permeability factor from a mother to her child. N. Engl. J. Med. 2001; 344(5): 386–387.
  • 29. Shankland S.J., Pollak M.R. A suPAR circulating factor causes kidney disease. Nat. Med. 2011; 17(8): 926–927.
  • 30. Reiser J., Wei C., Tumlin J. Soluble urokinase receptor and focal seg-mental glomerulosclerosis. Curr. Opin. Nephrol. Hypertens. 2012; 21(4): 428–432.
  • 31. Wei C., Sigdel T.K., Sarwal M.M., Reiser J. Circulating CD40 autoanti-body and suPAR synergy drives glomerular injury. Ann. Transl. Med. 2015; 3(19): 300.
  • 32. Go A.S., Chertow G.M., Fan D., McCulloch C.E., Hsu C.Y. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N. Eng. J. Med. 2004; 351(13): 1296–1305.
  • 33. Henry R.M., Kostense P.J., Bos G., Dekker J.M., Nijpels G., Heine R.J., Bouter L.M., Stehouwer C.D. Mild renal insufficiency is associated with increased cardiovascular mortality: The Hoorn Study. Kidney Int. 2002; 62(4): 1402–1407.
  • 34. Piotrowski W., Waśkiewicz A., Cicha-Mikołajczyk A. Global cardiovascular mortality risk in the adult Polish population: prospective assessment of the cohorts studied in multicentre national WOBASZ and WOBASZ Senior studies. Kardiol. Pol. 2016; 74(3): 262–273.
  • 35. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease. Kidney Int. Suppl. 2013; 3: 1–150.
  • 36. Inoue A., Wada H., Takagi M., Yamamuro M., Mukai K., Nakasaki T., Shimura M., Hiyoyama K., Deguchi H., Gabazza E.C., Mori Y., Nishikawa M., Deguchi K., Shiku H. Hemostatic abnormalities in patients with throm-botic complications on maintenance hemodialysis. Clin. App. Thromb. Hemost. 2000; 6(2): 100–103.
  • 37. Morange P.E., Bickel C., Nicaud V., Schnabel R., Rupprecht H.J., Peetz D., Lackner K.J., Cambien F., Blankenberg S., Tiret L. Haemostatic factors and the risk of cardiovascular death in patients with coronary artery disease: the AtheroGene study. Arterioscler. Thromb. Vasc. Biol. 2006; 26(12): 2793––2797.
  • 38. Sakkinen P.A., Cushman M., Psaty B.M., Rodriguez B., Boineau R., Kuller L.H., Tracy R.P. Relationship of plasmin generation to cardiovascular disease risk factors in elderly men and women. Arterioscler. Thromb. Vasc. Biol. 1999; 19(3): 499–504.
  • 39. Mezzano D., Tagle R., Panes O., Pérez M., Downey P., Muñoz B., Aranda E., Barja P., Thambo S., González F., Mezzano S., Pereira J. Hemostatic disorder of uremia: the platelet defect, main determinant of the prolonged bleeding time, is correlated with indices of activation of coagulation and fibrinolysis. Thromb. Haemost. 1996; 76(3): 312–321.
  • 40. Ito T., Niwa T., Matsui E. Fibrinolytic activity in renal disease. Clin. Chim. Acta 1972; 36(1): 145–151.
  • 41. Pawlak K., Pawlak D., Myśliwiec M. Excess soluble urokinase-type plasminogen activator receptor in the plasma of dialysis patients correlates with increased fibrinolytic activity. Thromb. Res. 2007; 119(4): 475–480.
  • 42. Pawlak K., Pawlak D., Myśliwiec M. Tissue factor and urokinase-type plazminogen activator system are related to the presence of cardiovascular disease in hemodialysis patients. Thromb. Res. 2007; 120(6): 871–876.
  • 43. Pawlak K., Ulazka B., Myśliwiec M., Pawlak D. Vascular endothelial growth factor and uPA/suPAR system in early and advanced chronic kidney disease patients: a new link between angiogenesis and hyperfibrinolysis? Transl. Res. 2012; 160(5): 346–354.
  • 44. Makin A. J., Chung N.A., Silverman S.H., Lip G.Y. Vascular endothelial growth factor and tissue factor in patients with established peripheral artery disease: a link between angiogenesis and thrombogenesis? Clin. Sci. 2003; 104(4): 397–404.
  • 45. Migdalski A., Kotschy M., Jawien A. Tissue factor, tissue factor path-way inhibitor and vascular endothelial growth factor-A in carotid atherosclerotic plaques. Eur. J. Vasc. Endovasc. Surg. 2005; 30(1): 41–47.
  • 46. Shen B.Q., Lee D.Y., Cortopassi K.M., Damico L.A., Zioncheck T.F. Vascular endothelial growth factor KDR receptor signaling potentiates tumor necrosis factor-induced tissue factor expression in endothelial cells. J. Biol. Chem. 2001; 276(7): 5281–5286.
  • 47. Kroon M.E., Koolwijk P., Vermeer M.A., van der Vecht B., van Hinsbergh V.W. Vascular endothelial growth factor enhances the expression of urokinase receptor in human endothelial cells via protein kinase C activation. Thromb. Haemost. 2001; 85(2): 296–302.
  • 48. Blann A.D., Belgore F.M., McCollum C.N., Silverman S., Lip P.L., Lip G.Y. Vascular endothelial growth factor and its receptor, Flt-1, in the plasma of patients with coronary or peripheral atherosclerosis, or type II diabetes. Clin. Sci. 2002; 102(2): 187–194.
  • 49. Toschi V., Gallo R., Lettino M., Fallon J.T., Gertz S.D., Fernández-Ortiz A., Chesebro J.H., Badimon L., Nemerson Y., Fuster V., Badimon J.J. Tissue factor modulates the thrombogenicity of human atherosclerotic plaques. Circulation 1997; 95(3): 594–599.
  • 50. Khurana R., Simons M., Martin J.F., Zachary I.C. Role of angiogenesis in cardiovascular disease: a critical appraisal. Circulation 2005; 112(12): 1813–1824.
  • 51. Pawlak K., Buraczewska-Buczko A., Myśliwiec M., Pawlak D. Hyper-fibrinolysis, uPA/suPAR system, kynurenines, and the prevalence of cardio-vascular disease in patients with chronic renal failure on conservative treatment. Am. J. Med. Sci. 2010; 339(1): 5–9.
  • 52. Prager G.W., Breuss J.M., Streurer S., Mihaly J., Binder B.R. Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells. Blood 2004; 103(3): 955-62.
  • 53. Houck K.A., Leung D.W., Rowland A.M., Winer J., Ferrara N. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J. Biol. Chem. 1992; 267(36): 26031–26037.
  • 54. Tang W.H., Friess H., di Mola F.F., Schilling M., Maurer C., Graber H.V., Dervenis C., Zimmermann A., Büchler M.W. Activation of the serine proteinase system in chronic kidney rejection. Transplantation 1998; 65(12): 1628–1634.
  • 55. Gueler F., Rong S., Mengel M., Park J.K., Kiyan J., Kirsch T., Dumler I., Haller H., Shushakova N. Renal urokinase-type plasminogen activator (uPA) receptor but not uPA deficiency strongly attenuates ischemia reperfusion injury and acute kidney allograft rejection. J. Immunol. 2008; 181(2): 1179–1189.
  • 56. Fuhrman B. The urokinase system in the pathogenesis of atherosclerosis. Atherosclerosis 2012; 222(1): 8–14.
  • 57. Stenvinkel P. Malnutrition and chronic inflammation as risk factors for cardiovascular disease in chronic renal failure. Blood Purif. 2001; 19: 143–151.
  • 58. Almroth G., Lonn J., Uhlin F., Nayeri F., Brudin L., Andersson B., Hahn-Zoric M. Fibroblast growth factor 23, hepatocyte growth factor, interleukin-6, high-sensitivity C-reactive protein and soluble urokinase plasminogen activator receptor. Inflammation markers in chronic haemodialysis patients? Scand. J. Immunol. 2013; 78(3): 285–290.
  • 59. Anand N., Chandrasekaran S.C., Alam M.N. The malnutrition inflamma-tion complex syndrome- the missing factor in the perio-chronic kidney disease interlink. J. Clin. Diagn. Res. 2013; 7(4): 763–767.
  • 60. Pecoits-Filho R., Lindholm B., Stenvinkel P. The malnutrition, inflam-mation, and atherosclerosis (MIA) syndrome – the heart of the matter. Nephrol. Dial. Transplant. 2002; 17: 28–31.
  • 61. Stenvinkel P., Heimburger O., Lindholm B., Kaysen G.A., Bergstrom J. Are there two types of malnutrition in chronic renal failure? Evidence for relationships between malnutrition, inflammation and atherosclerosis (MIA syndrome). Nephrol. Dial. Transplant. 2000; 15: 953–960.
  • 62. Almroth G., Lonn J., Uhlin F., Brudin L., Andersson B., Hahn-Zoric M. Sclerostin, TNF-alpha and interleukin-18 correlate and are together with Klotho related to other growth factors and cytokines in haemodialysis patients. Scand. J. Immunol. 2016; 83(1): 58–63.
  • 63. Pelletier S., Dubourg L., Carlier M.C., Hadj-Aissa A., Fouque D. The relation between renal function and serum sclerostin in adult patients with CKD. Clin. J. Am. Soc. Nephrol. 2013; 8: 819–823.
  • 64. Desjardins L., Liabeuf S., Olivieira R.B., Louvet L., Kamel S., Lemke H.D., Vanholder R., Choukroun G., Massy Z.A. Uremic toxicity and scle-rostin in chronic kidney disease patients. Nephrol. Ther. 2014; 10: 463–470.
  • 65. Kirkpantur A., Balci M., Turkvatan A., Afsar B. Independent associa-tion between serum sclerostin levels and carotid artery atherosclerosis in prevalent haemodialysis patients. 2015 Clin. Kidney J. 2015; 8(6): 737–743.
  • 66. Liu Y.W., Su C.T., Chang Y.T., Tsai W.C., Su Y.R., Wang S.P., Yang C.S., Tsai L.M., Chen J.H., Sung J.M. Elevated serum interleukin-18 level is associated with all-cause mortality in stable hemodialysis patients inde-pendently of cardiac dysfunction. PLoS One 2014; 9(3): e89457.
  • 67. Andersen O., Eugen-Olsen J., Kofoed K., Iversen J., Haugaard SB. Soluble urokinase plasminogen activator receptor is a marker of dysmetabo-lism in HIV-infected patients receiving highly active antiretroviral therapy. J. Med. Virol. 2008; 80(2): 209–216.
  • 68. Riisbro R., Christensen I.J., Hogdall C., Brunner N., Hogdall E. Soluble urokinase plasminogen activator receptor measurements: influence of sample handling. Int. J. Biol. Markers 2001; 16(4): 233–239.
  • 69. Sier C.F., Sidenius N., Mariani A., Aletti G., Agape V., Ferrari A., Casetta G., Stephens R.W., Brünner N., Blasi F. Presence of urokinase-type plasminogen activator receptor in urine of cancer patients and its possible clinical relevance. Lab. Invest. 1999; 79(6): 717–722.
  • 70. Mustjoki S., Sidenius N., Sier C.F., Blasi F., Elonen E., Alitalo R., Vaheri A. Soluble urokinase receptor levels correlate with number of circulating tumor cells in acute myeloid leukemia and decrease rapidly during chemotherapy. Cancer Res. 2000; 60(24): 7126–7132.
  • 71. Hayek S.S., Sever S., Ko Y.A., Trachtman H., Awad M., Wadhwani S., Altintas M.M., Wei C., Hotton A.L., French A.L., Sperling L.S., Lerakis S., Quyyumi A.A., Reiser J. Soluble urokinase receptor and chronic kidney disease. N. Engl. J. Med. 2015; 373, 20: 1916–1925.
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-0b667e6f-a583-48fb-9693-8f64389bb03a
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.