Preferences help
enabled [disable] Abstract
Number of results
2019 | 117 | 147-157
Article title

The importance of intestinal dysbiosis in mood disorders

Title variants
Languages of publication
Intestinal bacteria and the microbiota-brain-intestin axis have been the subject of intense research in the last decade. Until recently, it seemed unlikely to combine fecal microflora with mood disorders. The growing amount of animal research shows that one of the etiological factors of mood disorders may be irregularities in this area. Evidence indicates the existence of an extremely important two-way relationship between bacteria, intestines and the brain, and that this interaction is complex and takes place on many levels. Understanding and analyzing this dependency gives new possibilities in the therapy of mood disorders, such as the use of psychobiotics, prebiotics or drugs which selectively eliminate specific bacterial strains (antimicrobials). Psychobiotics are „good” bacteria which, when consumed in appropriate doses, have a positive effect on the intestinal axis and on the condition of patients with mental disorders. Studies on their use show good results in the treatment of diseases such as depression. In people suffering from depression, significant differences in the composition of the intestinal microflora were observed, which speaks for its essential role in this disease. Even greater role of bacteria in mood disorders favors research that proves that fecal microbiota transplant entails consequences in the form of behavioral changes.
Physical description
  • Student Science Club at the Department of Applied Psychology, Medical University of Lublin, Lublin, Poland
  • Student Science Club at the Department of Applied Psychology, Medical University of Lublin, Lublin, Poland
  • Student Science Club at the Department of Applied Psychology, Medical University of Lublin, Lublin, Poland
  • Student Science Club at the Department of Applied Psychology, Medical University of Lublin, Lublin, Poland
  • Department of Applied Psychology, Medical University of Lublin, Lublin, Poland
  • Department of Applied Psychology, Medical University of Lublin, Lublin, Poland
  • [1] S.H. Rhee, C. Pothoulakis, E.A Mayer, Principles and clinical implications of the brain-gut-enteric microbiota axis. Nature reviews. Gastroenterology & hepatology, 6(5) (2009) 306-14.
  • [2] M.C Cenit, Y. Sanz, P. Codoñer-Franch, Influence of gut microbiota on neuropsychiatric disorders. World journal of gastroenterology, 23(30) (2017) 5486-5498.
  • [3] S.K. Mazmanian, J.L Round, D.L Kasper, A microbial symbiosis factor prevents intestinal inflammatory disease. Nature, 29; 453 (7195) (2008) 620-625
  • [4] Koopman, Margree, El Aidy, Sahar, Depressed gut? The microbiota-diet-inflammation trialogue in depression. Current Opinion in Psychiatry, 30(5) (2017) 369-377.
  • [5] H. Karakuła-Juchnowicz, H. Pankowicz, D. Juchnowicz, P. Szachta, T. Małecka-Massalska, Psychobiotics: new possibilities for treatment of affective disorders? Pharmacotherapy in Psychiatry and Neurology, 31(3-4) (2015) 229-242.
  • [6] H.X. Wang, Y.P. Wang, Gut Microbiota-brain Axis. Chinese medical journal, 129(19) (2016) 2373-2380.
  • [7] A.I Petra, S. Panagiotidou, E. Hatziagelaki, J.M. Stewart, P. Conti, T.C. Theoharides, Gut-Microbiota-Brain Axis and Its Effect on Neuropsychiatric Disorders With Suspected Immune Dysregulation. Clinical therapeutics, 37(5) (2015) 984-995.
  • [8] E.A. Mayer, Gut feelings: the emerging biology of gut-brain communication. Nature reviews. Neuroscience, 12(8) (2011) 453-466.
  • [9] D. Erny, A.L. Hrabě de Angelis, D. Jaitin, P. Wieghofer, O. Staszewski, E. David, H. Keren-Shaul, T. Mahlakoiv, K. Jakobshagen, T. Buch, V. Schwierzeck, O. Utermöhlen, E. Chun, W.S. Garrett, K.D. McCoy, A. Diefenbach, P. Staeheli, B. Stecher, I. Amit, M. Prinz, Host microbiota constantly control maturation and function of microglia in the CNS. Nature neuroscience, 18(7) (2015) 965-977.
  • [10] G.J. Harry, Microglia during development and aging. Pharmacology & therapeutics, 139(3) (2013) 313-326.
  • [11] K.M. Neufeld, N. Kang, J. Bienenstock, J.A. Foster, Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterol Motil. 23(3) (2011) 255-264.
  • [12] N. Sudo, Y. Chida, Y. Aiba, J. Sonoda, N. Oyama, X.N. Yu, C. Kubo, Y. Koga, Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. The Journal of physiology, 558(1) (2004) 263-275.
  • [13] E.E Fröhlich, A. Farzi, R. Mayerhofer, F. Reichmann, A. Jačan, B. Wagner, E. Zinser, N. Bordag, C. Magnes, E. Fröhlich, K. Kashofer, G. Gorkiewicz, P. Holzer, Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication. Brain, behavior, and immunity, 56 (2016) 140-155.
  • [14] S. Macfarlane, J. Dillon, Microbial biofilms in the human gastrointestinal tract. Journal of Applied Microbiology, 102 (2007) 1187-1196.
  • [15] I.D. Van Felius, L.M. Akkermans, K. Bosscha, A. Verheem, W. Harmsen, M.R. Visser, H.G. Gooszen, Interdigestive small bowel motility and duodenal bacterial overgrowth in experimental acute pancreatitis. Neurogastroenterology & Motility, 15 (2003) 267-276.
  • [16] J. Groot, P. Bijlsma, A.V. Kalkeren, A. Kiliaan, P. Saunders, M. Perdue, Stress‐Induced Decrease of the Intestinal Barrier Function: The Role of Muscarinic Receptor Activation. Annals of the New York Academy of Sciences, 915 (2000) 237-246.
  • [17] A.D. Yates, J. Santos, J.D. Söderholm, M.H. Perdue, Adaptation of stress-induced mucosal pathophysiology in rat colon involves opioid pathways. American Journal of Physiology-Gastrointestinal and Liver Physiology, 2001 281(1) (2001) 124-128.
  • [18] E.A. Mayer, K. Tillisch, A. Gupta, Gut/brain axis and the microbiota. The Journal of clinical investigation, 125(3) (2015) 926-938.
  • [19] R. L. Stephens, Y. Tache, Intracisternal injection of a TRH analogue stimulates gastric luminal serotonin release in rats. American Journal of Physiology-Gastrointestinal and Liver Physiology, 256(2) (1989) 377-383.
  • [20] W.R. Wikoff, A.T. Anfora, J. Liu, P.G. Schultz, S.A. Lesley, E.C. Peters, G. Siuzdak, Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proceedings of the National Academy of Sciences of the United States of America, 106(10) (2009) 3698-3703.
  • [21] J.R. Cannon, J.T.Greenamyre, The role of environmental exposures in neurodegeneration and neurodegenerative diseases. Toxicological Sciences : an official Journal of the Society of Toxicology, 124(2) (2011) 225-250.
  • [22] J.F. Cryan, T.G. Dinan, More than a gut feeling: the microbiota regulates neurodevelopment and behavior. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology, 40(1) (2014) 241-242.
  • [23] R.M. Stilling, T.G. Dinan, J.F. Cryan, Microbial genes, brain & amp; behaviour - epigenetic regulation of the gut-brain axis. Genes Brain Behav. 13 (2014) 69-86.
  • [24] K.M. Van Loo, G.J. Martens, Genetic and environmental factors in complex neurodevelopmental disorders. Current genomics, 8(7) (2007) 429-44.
  • [25] S.M. O'Mahony, G. Clarke, Y.E. Borre, T.G. Dinan, J.F. Cryan, Serotonin, tryptophan metabolism and the brain-gut-microbiome axis. Behav Brain Res. 277 (2015) 32-48.
  • [26] S. Migliarini, G. Pacini, B. Pelosi, G. Lunardi, M. Pasqualetti, Lack of brain serotonin affects postnatal development and serotonergic neuronal circuitry formation. Mol Psychiatry, 18 (2013) 1106-1118
  • [27] Y. Obata, Y. Furusawa, K. Hase, Epigenetic modifications of the immune system in health and disease. Immunol Cell Biol. 93 (2015) 226–232.
  • [28] T.G Dinan, J.F. Cryan, Mood by microbe: towards clinical translation. Genome medicine, 8(1) (2016) 36.
  • [29] E. Aizawa, H. Tsuji, T. Asahara, T. Takahashi, T. Teraishi, S. Yoshida, M. Ota, N. Koga, K. Hattori, H. Kunugi, Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder. J Affect Disord. 202 (2016) 254–257.
  • [30] H. Jiang, Z. Ling, Y. Zhang, H. Mao, Z. Ma, Y. Yin, W. Wang, W. Tang, Z. Tan, J. Shi, L. Li, B. Ruan, Altered fecal microbiota composition in patients with major depressive disorder. Brain Behav Immun. 48 (2015) 186–194.
  • [31] S. Gnanavel, Psychobiotics: the latest psychotropics. Indian journal of psychological medicine, 37(1) (2015) 110.
  • [32] Sarkar, S.M. Lehto, S. Harty, T.G. Dinan, J.F. Cryan, P. Burnet, Psychobiotics and the Manipulation of Bacteria-Gut-Brain Signals. Trends in neurosciences, 39(11) (2016) 763-781.
  • [33] S.M. Ross. Microbiota in Neuropsychiatry, Part 3: Psychobiotics as Modulators of Mood Disorders. Holist Nurs Pract. 31(4) (2017) 270–273.
  • [34] C. Ménard, G.E. Hodes, S.J. Russo, Pathogenesis of depression: Insights from human and rodent studies. Neuroscience, 321 (2015) 138-162.
  • [35] J.A. Bravo, P. Forsythe, M.V. Chew, E. Escaravage, H.M. Savignac, T.G. Dinan, J. Bienenstock, J.F. Cryan, Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proceedings of the National Academy of Sciences of the United States of America, 108(38) (2011) 16050-16055.
  • [36] L. Zhou, J.A. Foster, Psychobiotics and the gut-brain axis: in the pursuit of happiness. Neuropsychiatric disease and treatment, 11 (2015) 715-723.
  • [37] D. Benton, C. Williams, A. Brown, Impact of consuming a milk drink containing a probiotic on mood and cognition. European Journal of Clinical Nutrition, 61 (2007) 355–361.
  • [38] R. Huang, K. Wang, J. Hu, Effect of Probiotics on Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 8(8) (2016) 483.
  • [39] S. Liang, X. Wu, X. Hu, T. Wang, F. Jin, Recognizing Depression from the Microbiota⁻Gut⁻Brain Axis. International journal of molecular sciences, 19(6) (2018) 1592.
  • [40] I.M. Husain, I.B. Chaudhry, R.R. Rahman, M.M. Hamirani, I. Qurashi, A.B. Khoso, J.F. Deakin, N. Husain, A.H. Young, Minocycline as an adjunct for treatment-resistant depressive symptoms: study protocol for a pilot randomised controlled trial. Trials, 16 (2015) 410.
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.