Udział VEGF-A i jego receptorów w procesie angiogenezy

• Authors: Anna M. Uttecht-Pudełko , Robert Partyka , Izabela Jałowiecka , Michał Żerdziński , Beata Pieczyrak , Danuta Kokocińska

Title variants

EN

The role of VEGF-A and its receptors in angiogenesis

• Languages of publication: PL

Abstracts

PL

Tworzenie naczyń krwionośnych jest niezbędne do prawidłowego rozwoju organizmu i przebiegu procesów naprawczych, ale też kluczowe w progresji choroby nowotworowej i generacji przerzutów odległych w guzach litych. Główną cytokiną promującą rozwój nowych naczyń krwionośnych jest naczyniowo-śródbłonkowy czynnik wzrostu VEGF (vascular endothelial growth factor), natomiast jego rozpuszczalne receptory (sVEGF-R1 i sVEGF-R2), w związku z wychwytywaniem wolnych cząsteczek VEGF-A oraz ich neutralizacją, charakteryzuje aktywność antyangiogenna.

EN

Angiogenesis is essential for the proper development of the organism and repair processes, but also significant in cancer progression and metastasis in solid tumors. A major cytokine that promotes the development of new blood vessels is the vascular endothelial growth factor – VEGF, whereas its soluble receptors (sVEGF-R1 and sVEGF-R2) perform antiangiogenic activity because they capture and neutralize VEGF-A free molecules.

Keywords

EN

VEGF-A; angiogeneza; sVEGF-R1; sVEGF-R2; sVEGF-R2angiogenesis

Discipline

• MEDICINE: MEDICINE

• Publisher: Śląski Uniwersytet Medyczny w Katowicach
• Journal: Annales Academiae Medicae Silesiensis
• Year: 2014
• Volume: 68
• Issue: 6
• Pages: 457–464

Contributors

author

Anna M. Uttecht-Pudełko

• Oddział Kliniczny Anestezjologii i Intensywnej Terapii Katedry Anestezjologii, Intensywnej Terapii i Medycyny Ratunkowej Wydziału Lekarskiego z Oddziałem Lekarsko-Dentystycznym w Zabrzu Śląskiego Uniwersytetu Medycznego w Katowicach Wojewódzki Szpital Specjalistyczny im. Św. Barbary Pl. Medyków 1 41-200 Sosnowiec tel. [phone]

author

Robert Partyka

• Oddział Kliniczny Anestezjologii i Intensywnej Terapii Katedry Anestezjologii, Intensywnej Terapii i Medycyny Ratunkowej Wydziału Lekarskiego z Oddziałem Lekarsko-Dentystycznym w Zabrzu Śląskiego Uniwersytetu Medycznego w Katowicach

author

Izabela Jałowiecka

• Oddział Kliniczny Anestezjologii i Intensywnej Terapii Katedry Anestezjologii, Intensywnej Terapii i Medycyny Ratunkowej Wydziału Lekarskiego z Oddziałem Lekarsko-Dentystycznym w Zabrzu Śląskiego Uniwersytetu Medycznego w Katowicach

author

Michał Żerdziński

• Wojewódzki Szpital Specjalistyczny nr 5 im. Św. Barbary w Sosnowcu

author

Beata Pieczyrak

• Wojewódzki Szpital Specjalistyczny nr 5 im. Św. Barbary w Sosnowcu

author

Danuta Kokocińska

• Oddział Kliniczny Anestezjologii i Intensywnej Terapii Katedry Anestezjologii, Intensywnej Terapii i Medycyny Ratunkowej Wydziału Lekarskiego z Oddziałem Lekarsko-Dentystycznym w Zabrzu Śląskiego Uniwersytetu Medycznego w Katowicach

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• Document Type: article