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2020 | 10 | 4 | 123-129

Article title

Stereotactic management of arrhythmia – radiosurgery in treatment of ventricular tachycardia (SMART-VT) – clinical trial protocol and study rationale


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Patients with ventricular tachycardia are usually treated with antiarrhythmic drugs and ablation if the arrhythmia substrate is available for invasive treatment. Despite high efficiency of this treatment there is a significant group of patients who do not benefit from available treatment methods, either because they cannot be applied or do not allow for durable control of the disease. For that reason a novel treatment method, STereotactic Arrhythmia Radioablation (STAR) has been proposed and its safety and efficiency is extensively studied throughout the world. The method is based on irradiation of the arrhythmia substrate identified with electrophysiological examination with high-precision image-guided radiosurgical methods usually used for ablation of malignant tumors. Here we present the protocol of the first Polish study on STAR in patients with intractable ventricular tachycardia (STARVT, NCT04642963), designed to test the safety of the method. Secondary endpoints include measures of the treatment efficiency.











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  • III Department of Radiotherapy and Chemotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland
  • 1. Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland. 2. Interventional Cardiac Electrophysiology Group, International Clinical Research Center, St. Anne’s University Hospital Brno, Brno, Czech Republic
  • Department of Biostatistics and Translational Medicine, Medical University of Lodz, Lodz, Poland
  • Department of Radiotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland
  • Department of Electrocardiology, John Paul II Hospital, Cracow, Poland
  • Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland
  • 1. Department of Electrocardiology, Upper-Silesian Heart Center, Katowice, Poland. 2. Department of Electrocardiology and Heart Failure, Medical University of Silesia, Katowice, Poland
  • Department of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland
  • First Department of Cardiology, Medical University of Silesia, Katowice, Poland
  • Department of Radiotherapy Planning, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland
  • Department of Radiotherapy Planning, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland
  • Department of Radiotherapy, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice, Poland


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