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2013 | 18 | 18 | 157-165
Article title

THE INFLUENCE OF THE PHYSICOCHEMICAL FACTORS ON DISSOLUTION OF THE SUBSTANCE OF CLASS II BCS FROM SOLID DISPERSIONS WITH CHITOSAN

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EN
Abstracts
EN
The BCS class II includes drugs with low solubility and high permeability. Fenofibrate is an example of this class drugs. The aim of the study was to investigate the effect of chitosan about average molecular weight in various formulations on the dissolution of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions using a method of the solvent evaporations at the drug to polymer ratio of 1:9;3:7;5:5.
The highest dissolution of fenofibrate, amounting to 72.7%, was observed after 60 minutes from solid dispersions with drug-polymer weight ratio 1:9 in the presence chitosan A and was72 times higher in relation to the amount of added polymer in comparison to the solubility of pure drug.
Investigations DSC showed that fenofibrate was remained in crystalline state in solid dispersion.
Year
Volume
18
Issue
18
Pages
157-165
Physical description
Contributors
  • Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw
  • Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw
author
  • Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw
author
  • Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw
References
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  • 2. Yasir M., Asif M., Kumar A., Aggarval A.;(2010) Biopharmaceutical Classification System: An Account; Int. J. of Pharm. Tech. Res. 2, pp. 1681-1690.
  • 3. Tejas Patel L. D Patel, Timir Patel, Sunil Makwana , Tushar Patel;(2010) Enhancement of dissolution of Fenofibrate by Solid dispersion Technique: Int. J. Res. Pharm. Sci. 1, pp. 127-132.
  • 4. Sucheta D. Bhise;1; (2011) Ternary Solid Dispersions of Fenofibrate with Poloxamer 188 and TPGS for Enhancement of Solubility And Bioavailability: Int. Journal of Research in Pharmaceutical and Biomedical Sciences 2, pp. 583-595.
  • 5. Vogt M, Kunath K, Dressman JB.; (2008).Dissolution enhancement of Fenofibrate by micronization, cogrinding. Eur J Pharm and Biopharm. 68, pp. 283-288.
  • 6. Elsabee MZ, Morsi RE, Al-Sabagh AM.; (2009) Surface active properties of chitosan and its derivatives. Colloids Surf B Biointerfaces. 1,74(1), pp. 1-16.
  • 7. Rao TV, Kumar GK, Ahmed MG, Joshi V.; (2012) Development and evaluation of chitosan based oral controlled matrix tablets of losartan potassium. Int J Pharm Investig. 2(3) pp.157-16.1
  • 8. Farmakopea Polska VIII, Warszawa: URPL i WB 2008, tom I, str. 1434-1435.
  • 9. Sun Y, Cui F, Shi K, Wang J, Niu M, Ma R.(2009) The effect of chitosan molecular weight on the characteristics of spray-dried methotrexate-loaded chitosan microspheres for nasal administration. Drug Dev Ind Pharm. 35(3)pp:379-86.
Document Type
article
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YADDA identifier
bwmeta1.element.psjd-09cd81e3-63e5-47bc-a6fc-f4056a9a419c
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