THE INFLUENCE OF THE PHYSICOCHEMICAL FACTORS ON DISSOLUTION OF THE SUBSTANCE OF CLASS II BCS FROM SOLID DISPERSIONS WITH CHITOSAN

• Authors: Bożena Grimling , Agata Górniak , Jan Meler , Janusz Pluta
• Languages of publication: EN

Abstracts

EN

The BCS class II includes drugs with low solubility and high permeability. Fenofibrate is an example of this class drugs. The aim of the study was to investigate the effect of chitosan about average molecular weight in various formulations on the dissolution of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions using a method of the solvent evaporations at the drug to polymer ratio of 1:9;3:7;5:5.
The highest dissolution of fenofibrate, amounting to 72.7%, was observed after 60 minutes from solid dispersions with drug-polymer weight ratio 1:9 in the presence chitosan A and was72 times higher in relation to the amount of added polymer in comparison to the solubility of pure drug.
Investigations DSC showed that fenofibrate was remained in crystalline state in solid dispersion.

Keywords

EN

different molecular weights of chitosan; fenofibrate; solid dispersion prepared solvent evaporation; solubility

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2013
• Volume: 18
• Issue: 18
• Pages: 157-165

Contributors

author

Bożena Grimling

• Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw

author

Agata Górniak

• Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw

author

Jan Meler

• Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw

author

Janusz Pluta

• Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw

References

• 1. Amidon G.L., Lennernäs H., Shah V.P., Crison J.R..;(1995) A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability. Pharm. Res. 12, pp. 413-420.
• 2. Yasir M., Asif M., Kumar A., Aggarval A.;(2010) Biopharmaceutical Classification System: An Account; Int. J. of Pharm. Tech. Res. 2, pp. 1681-1690.
• 3. Tejas Patel L. D Patel, Timir Patel, Sunil Makwana , Tushar Patel;(2010) Enhancement of dissolution of Fenofibrate by Solid dispersion Technique: Int. J. Res. Pharm. Sci. 1, pp. 127-132.
• 4. Sucheta D. Bhise;1; (2011) Ternary Solid Dispersions of Fenofibrate with Poloxamer 188 and TPGS for Enhancement of Solubility And Bioavailability: Int. Journal of Research in Pharmaceutical and Biomedical Sciences 2, pp. 583-595.
• 5. Vogt M, Kunath K, Dressman JB.; (2008).Dissolution enhancement of Fenofibrate by micronization, cogrinding. Eur J Pharm and Biopharm. 68, pp. 283-288.
• 6. Elsabee MZ, Morsi RE, Al-Sabagh AM.; (2009) Surface active properties of chitosan and its derivatives. Colloids Surf B Biointerfaces. 1,74(1), pp. 1-16.
• 7. Rao TV, Kumar GK, Ahmed MG, Joshi V.; (2012) Development and evaluation of chitosan based oral controlled matrix tablets of losartan potassium. Int J Pharm Investig. 2(3) pp.157-16.1
• 8. Farmakopea Polska VIII, Warszawa: URPL i WB 2008, tom I, str. 1434-1435.
• 9. Sun Y, Cui F, Shi K, Wang J, Niu M, Ma R.(2009) The effect of chitosan molecular weight on the characteristics of spray-dried methotrexate-loaded chitosan microspheres for nasal administration. Drug Dev Ind Pharm. 35(3)pp:379-86.

• Document Type: article