EFFECT OF A HYDROPHILISING SUBSTANCE ON THE VISCOSITY OF GYNAECOLOGICAL GELS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

• Authors: Katarzyna Małolepsza-Jarmołowska
• Languages of publication: EN

Abstracts

EN

Thus ensuring a continuous action of a drug also during daily activity time of a patient is a vital question in gynaecological treatment. The main problem in applied therapies is to maintain the continuity of treatment during 24 hours. The addition of 5-25% glycerol or 1,2-propylene glycol decreases the pH of investigated gels with calcium alginate to 4.20 to 4.88 (1:1) and 3.69 to 4.19 (2:1); 4.29 to 4.88 (1:1) and 3.62 to 4.40 (2:1). The addition of 5-25% glycerol or 1,2-propylene glycol increases the dynamic viscosity gels with calcium alginate from 595.14 to 820.25 for 1:1 and 640.15 to 769.12 for 2:1; 585.40 to 815.56 for 1:1 and 648.52 to 780.10 for 2:1 ratios. Rheological investigations revealed an increase in the dynamic viscosity of preparations containing poloxamer 407 with the addition of calcium alginate and glycerol or 1,2-propylene glycol in comparison to the reference gels.

Keywords

EN

anti-inflammatory drugs.; calcium alginate; hydrophilic gels; lactic acid complexed with chitosan; thermosensitive polymerpoloxamer 407; vaginal infections

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2012
• Volume: 17
• Pages: 125 - 132

Contributors

author

Katarzyna Małolepsza-Jarmołowska

• Faculty of Pharmacy The “Silesian Piasts” memorial Medical University of Wroclaw

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• Document Type: article