SWIMMING EXERCISE STIMULATES NEUROGENESIS IN THE SUBVENTRICULAR ZONE VIA INCREASE IN SYNAPSIN I AND NERVE GROWTH FACTOR LEVELS

• Authors: C-H Chae , S-L Jung , S-H An , B-Y Park , T-W Kim , S-W Wang , J-H Kim , H-C Lee , H-T Kim
• Languages of publication: EN

Abstracts

EN

In this study, we investigated the effects of 8-weeks of swimming exercise on neurogenesis in the subventricular zone (SVZ) and on the levels of nerve growth factor (NGF) and synapsin I protein in the olfactory bulb (OB) of adult rats at a series of relevant time points (2 days, 1 week, 2 weeks, 4 weeks, 3 months, and 6 months). Ninety-six male Sprague Dawley rats were divided into 2 groups: (1) a control group (COG; n = 48, n = 8 for each time point) and (2) a swimming exercise group (SEG; total n = 48; n = 8 for each time point). SEG performed swimming exercise for 5 days per week over a period of 8 weeks. We found that the number of 5-bromo-2'-deoxyuridine-5'-monophosphate (BrdU)- and doublecortin (DCX)-positive cells was significantly higher in SEG than in COG at all time points (Day 2, Week 1, Week 2, Week 4, Month 3, and Month 6; p < 0.001). Furthermore, NGF and synapsin I protein levels were significantly higher in SEG on Day 2, and Weeks 1, 2, and 4 than in COG (p < 0.05 for each time point). Our findings suggest that regular swimming exercise in adult rats increases neurogenesis, neuronal survival, and neuronal maintenance in the SVZ; furthermore, swimming exercise increases the levels of NGF and synapsin I in the OB.

Keywords

EN

brain; neurotrophic factors; olfactory bulb; physical training; progenitor cells; rats

Discipline

• MEDICINE: MEDICINE

• Publisher: Instytut Sportu
• Journal: Biology of Sport
• Year: 2014
• Volume: 31
• Issue: 4
• Pages: 309-314

Dates

published

2014

Contributors

author

C-H Chae

author

S-L Jung

author

S-H An

author

B-Y Park

author

T-W Kim

author

S-W Wang

author

J-H Kim

author

H-C Lee

author

H-T Kim

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• Document Type: article