Przeciwzapalna funkcja komórek mikrogleju w świetle najnowszych badań naukowych

• Authors: Krzysztof Łabuzek , Edyta Skrudlik , Bożena Gabryel , Bogusław Okopień

Title variants

EN

Anti-inflammatory microglial cell function in the light of the latest scientific research

• Languages of publication: PL

Abstracts

PL

Komórki mikrogleju są reprezentantami układu immunologicznego w ośrodkowym układzie nerwowym (OUN). Od dawna były postrzegane jako główny agresor, indukujący i podtrzymujący procesy zapalne i neurodegeneracyjne w OUN. Ostatnie doniesienia naukowe wskazują jednak, że mogą one pełnić istotną rolę ochronną. W niniejszej pracy przedstawiono dowody naukowe, podkreślające ich właściwości przeciwzapalne. Komórki mikrogleju podlegają aktywacji na dwa różne sposoby, co powoduje powstanie dwóch odmiennych fenotypów: klasycznego zapalnego oraz alternatywnego przeciwzapalnego. Ten ostatni charakteryzuje się m.in. ekspresją CD200 oraz fraktalkiny. Alternatywnie aktywowany mikroglej produkuje również cytokiny prozapalne, których wpływ na otaczające komórki nie do końca wiąże się tylko z ich destrukcją, lecz także niejednokrotnie z procesami neuroregeneracji i mielinizacji. Być może przedstawienie najnowszych doniesień skieruje uwagę badaczy na nowe narzędzia mogące znaleźć zastosowanie w zapobieganiu i leczeniu chorób OUN poprzez wykorzystanie przeciwzapalnych właściwości komórek, które wciąż uważa się za komórki prozapalne.

EN

Microglia represent the immune system in the central nervous system. They have long been regarded as as the main aggressor, which induce and support inflammatory and neurodegenerative processes in the central nervous system. The latest studies indicate that they can also play a protective role. In this study we present evidence underlying their anti-inflammatory properties. Microglia can be activated in two different ways and they have two different phenotypes: classical – pro-inflammatory and alternative – anti-inflammatory. The latter is characterized by CD200 expression and fractalkine. Alternatively, the activated microglia also produce pro-inflammatory cytokine. Their influence on the surrounding cells is associated not only with destruction but also with neuroregeneration and myelination. Perhaps the latest reports will draw researchers' attention to new solutions which may be used in the prevention and treatment of the central nervous system diseases through the anti-inflammatory properties of cells which are still seen as inflammatory cells.

Keywords

EN

CD200; IL-1; IL-6; TGF; TNF; alternative activation; alternatywna aktywacja; fractalkine; fraktalkina; microglia; mikroglej

Discipline

• MEDICINE: MEDICINE

• Publisher: Śląski Uniwersytet Medyczny w Katowicach
• Journal: Annales Academiae Medicae Silesiensis
• Year: 2015
• Volume: 69
• Pages: 99–110

Contributors

author

Krzysztof Łabuzek

• Katedra Farmakologii Śląskiego Uniwersytetu Medycznego w Katowicach, ul. Medyków 18, 40-752 Katowice, tel. [phone]

author

Edyta Skrudlik

• Katedra Farmakologii Śląskiego Uniwersytetu Medycznego w Katowicach

author

Bożena Gabryel

• Katedra Farmakologii Śląskiego Uniwersytetu Medycznego w Katowicach

author

Bogusław Okopień

• Katedra Farmakologii Śląskiego Uniwersytetu Medycznego w Katowicach

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• Document Type: article