Rola SPECT-DaTSCAN w diagnostyce izolowanego drżenia

• Authors: Agata Gajos , Janusz Dąbrowski , Małgorzata Bieńkiewicz , Jacek Kuśmierek , Andrzej Bogucki , Anna Płachcińska

Title variants

EN

The role of SPECT-DaTSCAN in the diagnosis of isolated tremor syndromes

• Languages of publication: EN

Abstracts

EN

Objectives: The purpose of our study was to determine the probability of developing Parkinson’s disease in various syndromes of isolated tremor. Material and methods: We performed a retrospective analysis of the diagnostic process in patients with isolated upper limb tremor where single-photon emission computed tomography (SPECT)-DaTSCAN was performed. Twenty-four consecutive subjects (9 males, 15 females) with isolated tremor of one or both upper limbs were studied. The patients were referred for SPECT by neurologists from various centres. Cases of diagnosed structural, metabolic or druginduced tremor were not included in the study. All patients were examined by a movement disorder specialist before and 1–3 years after SPECT-DaTSCAN. All subjects were classified according to the Consensus Statement on the Classification of Tremors (2018). Results: The lowest probability of developing Parkinson’s disease was found in patients with rest and action (postural and kinetic) tremor, both unilateral and bilateral. The risk was also low in subjects with postural and kinetic tremor. In cases of a combination of rest and postural tremor (both unilateral and bilateral), the likelihood of neurodegenerative parkinsonism was high. Conclusion: Performing SPECT-DaTSCAN in selected cases of isolated of tremor with a high probability of Parkinson’s disease avoids the unnecessary use of drugs recommended in the therapeutic algorithms applicable in essential tremor.

PL

Cele: Celem pracy była ocena ryzyka rozwinięcia się choroby Parkinsona w różnych postaciach drżenia izolowanego. Materiał i metody: Przeprowadzono retrospektywną analizę procesu diagnostycznego u pacjentów z izolowanym drżeniem kończyn górnych, u których wykonano badanie SPECT-DaTSCAN. Badaniem objęto grupę 24 kolejnych pacjentów (15 kobiet, 9 mężczyzn) z izolowanym drżeniem jednej lub obu kończyn górnych. Pacjenci byli kierowani na SPECT-DaTSCAN przez neurologów z różnych ośrodków. Do badanej grupy nie włączono osób ze stwierdzonymi zmianami strukturalnymi, metabolicznymi oraz przypadków drżenia polekowego. Wszyscy pacjenci byli badani przez specjalistę zaburzeń ruchowych przed badaniem SPECT-DaTSCAN i ponownie 1–3 lata później. Badane osoby były klasyfikowane zgodnie z opublikowanym w 2018 roku Consensus Statement on the Classification of Tremors. Wyniki: Najniższe ryzyko rozwinięcia się choroby Parkinsona stwierdzono w grupie chorych z współistniejącym drżeniem spoczynkowym i action tremor (posturalnym i kinetycznym), zarówno jedno- jak i obustronnym. Było ono także niskie u pacjentów ze współistnieniem drżenia posturalnego i kinetycznego. W przypadkach połączenia drżenia spoczynkowego i posturalnego prawdopodobieństwo parkinsonizmu neurozwyrodnieniowego było wysokie. Wnioski: Wykonywanie badania SPECT-DaTSCAN u wybranych pacjentów z izolowanym drżeniem z wysokim prawdopodobieństwem choroby Parkinsona pozwala uniknąć w tych przypadkach niepotrzebnego stosowania leków zalecanych w algorytmach terapeutycznych drżenia samoistnego.

Keywords

EN

SPECT-DaTSCAN; ryzyko choroby Parkinsona; zespoły izolowanego drżenia

Discipline

• MEDICINE: MEDICINE

• Publisher: Medical Communications
• Journal: Aktualności Neurologiczne
• Year: 2018
• Volume: 18
• Issue: 2
• Pages: 74–78

Contributors

author

Agata Gajos

• Department of Extrapyramidal Diseases, Medical University of Lodz, Łódź, Poland

author

Janusz Dąbrowski

• Department of Nuclear Medicine, Medical University of Lodz, Łódź, Poland

author

Małgorzata Bieńkiewicz

• Department of Quality Control and Radiological Protection, Medical University of Lodz, Łódź, Poland

author

Jacek Kuśmierek

• Department of Nuclear Medicine, Medical University of Lodz, Łódź, Poland

author

Andrzej Bogucki

• Department of Extrapyramidal Diseases, Medical University of Lodz, Łódź, Poland

author

Anna Płachcińska

• Department of Quality Control and Radiological Protection, Medical University of Lodz, Łódź, Poland

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• Document Type: article