Preferences help
enabled [disable] Abstract
Number of results
2013 | 67 | 1 | 47–51
Article title

What do we know about Kimura disease?

Title variants
Co powinniśmy wiedzieć o chorobie Kimury?
Languages of publication
This article describes Kimura’s disease as a rare case of lymphadenitis and reviews its epidemiology, clinical aspects, diagnosis and treatment methods. The role of surgical procedures was also underlined. Kimura disease is a rare and benign chronic inflammatory soft tissue disorder of unknown origin. The definitive histological description was published by Kimura et al. in 1948 and henceforth, the disease has born his name. Since that time, there has been a gradual increase in the number of reports. While most cases of Kimura disease have originated in China, Japan or Southeast Asia, there have been sporadic case reports from Europe and America. The data suggest that Kimura’s disease should be included in the list of differential diagnoses for all neck lymph node involvements. If a otolaryngologist maintains a high index of suspicion, an early diagnosis can be made to contribute to a more successful outcome of the disease.
Artykuł opisuje chorobę Kimury – rzadką przyczynę limfadenopatii, jej epidemiologię, objawy kliniczne, diagnostykę i leczenie, w tym leczenie chirurgiczne. Choroba Kimury jest rzadkim, łagodnym, przewlekłym zapaleniem tkanki łącznej nieznanego pochodzenia. Cechy histologiczne tej choroby zostały po raz pierwszy opisane przez Kimurę i wsp. w 1948 r. i nazwane jego nazwiskiem. Większość przypadków choroby Kimury pochodzi z Chin, Japonii bądź południowo-wschodniej Azji, natomiast nieliczne z Europy i Ameryki. Obraz kliniczny choroby nakazuje uwzględnienie jej w diagnostyce różnicowej powiększenia węzłów chłonnych szyi. Daje to możliwość pomyślnego wyleczenia.

Physical description
  • Department of Laryngology School of Medicine with Division of Dentistry in Zabrze of the Silesian Medical University in Katowice Department of Human Anatomy School of Medicine in Katowice of the Silesian Medical University in Katowice
  • Department of Patomorphology School of Medicine with Division of Dentistry in Zabrze of the Silesian Medical University in Katowice
  • Department of Patomorphology School of Medicine with Division of Dentistry in Zabrze of the Silesian Medical University in Katowice
  • Department of Laryngology School of Medicine with Division of Dentistry in Zabrze of the Silesian Medical University in Katowice
  • Department of Laryngology School of Medicine with Division of Dentistry in Zabrze of the Silesian Medical University in Katowice
  • 1. Turner R.R., Martin J., Dorfman R.F. Necrotizing lymphadenitis. A study of 30 cases. Am. J. Surg. Pathol. 1983; 7: 115–123.
  • 2. Park Y.W. Evaluation of neck masses in children. Am. Fam. Physician. 1995; 51: 1904–1912.
  • 3. Pileri S., Kikuchi M., Helbron D., Lennert K. Histiocytic necrotizing lymphadenitis without granulocytic infiltration. Virchows Arch. A. Pathol. Anat. Histol. 1982; 395: 257–271.
  • 4. Borkowski P., Dziubek Z. Lymphadenopathy in infections diseases. Post. Nauk Med. 2001; 14, 2: 14–18.
  • 5. Sun O.F., Xu D.Z., Pan S.H. et al. Kimura disease: revive of the literature. Int. Med. J. 2008; 38: 668–674.
  • 6. Thomas J., Jayachandran N.V., Chandrasekhara P.K.S., Rajasekhar L., Narisimulu G. Kimura’s disease – an unusual cause of lymphadenopathy in children. Clin. Rheumatol. 2008; 27: 675–677.
  • 7. Khan A., Bakhshi G.D., Patil K.K., Borse H.G., Govila A.A., Bhandarkar L.D. Kimura’s disease: a clinical case. Bombay Hospital Journal 2002; 44: 118–200.
  • 8. Larroche C., Bletry O. Kimura’s disease. Orphanet encyclopedia 2005; Feb: 1–3.
  • 9. Szporek B., Stęplewska K., Cieślik T. Choroba Kimura – opis przypadku. Czas. Stomatol. 2006; 59; 10: 734–739.
  • 10. Hobeika C., Mohammed T.L., Johnson G. Hanses K. Kimura’s disease. Case report and review of the literature. J. Thorac. Imaging 2005; 20; 4: 298–300.
  • 11. Wang D.Y., Mao J.H., Zhang Y., Zhao S.A., Chen Y.F., Liu A.M. Kimura Disease: a case report and review of the Chinese literature. Nephron. Clin. Pract. 2009; 111: 55–61.
  • 12. Zhang C., Hu J., Feng Z., Jin T. Kimura’s disease presenting as the middle mediastinal mass. Ann. Thor. Surg; 2009; 111; 1: 55–61.
  • 13. Abuel-Haija M., Hurford M. Kimura Disease. Arch. Pathol. Lab. Med. 2007; 131: 650–651.
  • 14. Masayuki S., Ayako K., Shinichi N. Hematoserological analysis of Kimura’s disease for optimal treatment. Otolaryngol. Head Neck Surg. 2005; 132: 159–60.
  • 15. Ohta N., Okazaki S., Fukase S., Akatsuka N., Aoyagi M., Yamakawa M. Serum concentrations of eosinophil cationic protein and eosinophils of patients with Kimura’s disease. Allergol. Int. 2007; 56: 45–49.
  • 16. Wang T.F., Liu S.H., Kao C.H., Chu S.C., Kao R.H., Li C.C. Kimura’s disease with generalized lymphadenopathy demonstrated by positron emission tomography scan. Intern. Med. 2006; 45: 775–778.
  • 17. Takeishi M., Makino Y., Nishioka H. et al. Kimura disease: diagnostic imaging findings and surgical treatment. J. Craniofac. Surg. 2007; 18: 1062–1067.
  • 18. Shan H.C., Li Y., Niu X.H. Two cases of eosinophilic lymphoid granuloma and literature review in Chinese. Cancer Progr. 2009; 7: 682–686.
  • 19. Xu L. A case of recurrent Kimura's disease in Chinese. J. Appl. Clin. Pediatr. 2006; 21: 1077.
  • 20. Long X. Childhood Kimura's disease: a case report in Chinese. Guizhou Med. J. 2009; 33: 1096.
  • 21. Xu X., Fu J., Fang Y., Liang L. Kimura disease: a case report and summary of the literature in Chine. J. Pediatr. Hematol. Oncol. 2011; 33; 4: 306–311.
  • 22. Cecen E., Kacar-Doger F., Etensel B. An extremaly case of generalized lymphadenopathy in children: Kimura’s disease. Turk. J. Pediatr. 2010; 52; 5: 534–537.
  • 23. Jiang Y., Zhao X.D., An L.F. et al. Eosinophilic lymphoid granuloma of bilateral neck: a case report in Chinese. J. Clin. Otorhi. Head. Neck. Surg. 2008; 22: 332–333.
  • 24. Li D.S., Chen Z.J., Lin B.H. et al. Analysis of clinical diagnosis and management of eosinophilic lymphoid granuloma in twenty-three patients. Guangdong Med. J. 2009; 30: 103–104.
  • 25. Liu C., Hu W., Chen H. et al. Clinical and pathological study of Kimura's disease with renal involvement. J. Nephrol. 2008; 21: 517–525.
  • 26. Uysal I.O., Erylimaz M.A., Salk I., Abasiyanik F. Kimura disease in the parotid gland. J. Craniofacial. Surg: 2011; 22; 1: 337–338.
  • 27. Chang A.R., Kim K., Kim H.J., Kim I.H., Park C.I., Jun Y.K. Outcomes of Kimura’s disease after radiotherapy or nonradiotherapeutic treatment modalities. Int. J. Radiat. Oncol. Biol. Phys. 2006; 65: 1233–1239.
  • 28. Maleki D., Sayyah A., Rahimi-Red M., Gholami N. Kimura’s disease with eosinophilic panniculitis – treated with cyclosporine: a case report. Allergy Asthma Clin. Immunonol. 2010; 6: 5–8.
  • 29. Sato S., Kawashima H., Kuboshima S. et al. Combined treatment of steroids and cyclosporine in Kimura disease. Pediatrics 2006; 118: 921–923.
  • 30. Soeria-Atmadija S., Oskarsson T., Ceki G., Sander B., Berg V., Gustafsson B. Maintenance of remission with cyclosporine in paediatric patients with Kimura’s disease – two case report. Acta Pediatr. 2011; 100: 186–189.
  • 31. Dai L., Wei X.N., Zheng D.H., Mo Y.Q., Pessler F., Zhang B.Y. Effective treatment of Kimura’s disease with leflunonide in combination with glucocorticoids. Clin. Rheumatol. 2011; 30: 859–865.
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.