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For developed new eco-friendly synthetic route for the synthesis of organic compounds, here in, we have synthesized new series of thiazole derivatives 7(a-h) under microwave irradiation method using less amount of methanol as solvent and less hazardous K2CO3 as catalyst. Then after for the pharmacokinetic study, we can calculate Lipinski rules of five data using swiss ADME software, molecule 7f was fitted in ‘rules of five’ (Ro5) other compounds are showed violence in log P(o/w). The structures of all synthesized compounds are well characterized by Mass, 1H NMR, 13C NMR.
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277-284
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- National Facility for Drug Discovery Centre, Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India
author
- National Facility for Drug Discovery Centre, Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India
author
- National Facility for Drug Discovery Centre, Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India
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Document Type
short_communication
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bwmeta1.element.psjd-008d5dcb-b742-41e4-b566-5a2f38054db1