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2019 | 132 | 277-284
Article title

Synthesis and pharmacokinetic study of new thiazole derivatives containing pyrazole moiety

Content
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Languages of publication
EN
Abstracts
EN
For developed new eco-friendly synthetic route for the synthesis of organic compounds, here in, we have synthesized new series of thiazole derivatives 7(a-h) under microwave irradiation method using less amount of methanol as solvent and less hazardous K2CO3 as catalyst. Then after for the pharmacokinetic study, we can calculate Lipinski rules of five data using swiss ADME software, molecule 7f was fitted in ‘rules of five’ (Ro5) other compounds are showed violence in log P(o/w). The structures of all synthesized compounds are well characterized by Mass, 1H NMR, 13C NMR.
Year
Volume
132
Pages
277-284
Physical description
Contributors
  • National Facility for Drug Discovery Centre, Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India
author
  • National Facility for Drug Discovery Centre, Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India
  • National Facility for Drug Discovery Centre, Department of Chemistry, Saurashtra University, Rajkot - 360005, Gujarat, India
References
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Document Type
short_communication
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-008d5dcb-b742-41e4-b566-5a2f38054db1
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