PL EN


Preferences help
enabled [disable] Abstract
Number of results
2016 | 21 | 187-191
Article title

THE INFLUENCE OF SUBSTRATE COMPOSITION ON THE PHYSICOCHEMICAL PROPERTIES OF HYDROGELS WITH CHITOSAN

Content
Title variants
Languages of publication
EN
Abstracts
EN
The aim of the study was to evaluate the effect of Carbopol 934 P and PVP K 90 on the rheological properties of chitosan gels. Hydrogels were prepared with hydrocortisone containing chitosan, Carbopl 934P, PVP, propylene glycol-1,2 or polyethyleneglycol 400 and glycerol. Addition of polymers had positive influence on the dispersion of hydrogels. The studied gels have thixotropic properties, their viscosity increases with the increase of the concentration of polymers. Increase of the content of polyvinylpyrrolidone K 90 and Carbopol 934 P increases the consistence, gels are more firm and cohesive. Gels with 5 % chitosane, 15% polyvinylpyrrolidone K 90 and Carbopol 934 P in the presence of additives have prolonged half release period of hydrocortisone.
Publisher

Year
Volume
21
Pages
187-191
Physical description
Contributors
  • THE INFLUENCE OF SUBSTRATE COMPOSITION ON THE PHYSICOCHEMICAL PROPERTIES OF HYDROGELS WITH CHITOSAN
author
  • THE INFLUENCE OF SUBSTRATE COMPOSITION ON THE PHYSICOCHEMICAL PROPERTIES OF HYDROGELS WITH CHITOSAN
author
  • THE INFLUENCE OF SUBSTRATE COMPOSITION ON THE PHYSICOCHEMICAL PROPERTIES OF HYDROGELS WITH CHITOSAN
References
  • [1] Wach R.A, Olejnik A.K, Kik D, Rosiak J.M ; (2008) Opatrunki hydrożelowe do leczenia oparzeń. Farm Pol 64, 11,516-521.
  • [2] Zgoda M.M, Kołodziejska J; (2008) The polyacrylic acid polymers as modern auxiliary applied in the manufacturing of the pharmaceutical products administered to the skin, suspensions and the bioadhesive forms of a drug with prolonged activity. Farm Pol 64, 2 ,73-83.
  • [3] Szcześniak M, Pluta J; (2011) Influence of polymers on hydrogels with hydrocortisone properties. Polim Med 41, 43-47.
  • [4] Szcześniak M, Pluta J; (2011) Infuence of hydrophiling agents on gel formation rate on Carbopol base. Polim Med 41, 27-32.
  • [5] Kubiak T; ( 2014) The use of shells made of poly(ethylene glycol) and chitosan to ensure the biocompatibility of nanoparticles in biomedical applications. Polim Med.44,2, 119-127.
  • [6] Mazurek P, Kuliński S, Gosak J; (2013) The Possibilities of using a Chitin and Chitosan in wounds treatment. Polim Med 43, 4, 297-302.
  • [7] Matusowa D, Vitkova Z, Truplowa E, Herdova P; (2010) Chitosan hydrogel with terbinafine – an evaluation of drug release. Pharmazie 65, 523-524.
  • [8] Anitha A, Sowmya S, Sudheesh Kumar P.T, Deepathi S, Chennazhi K.P, Ehrlich H, Tsurkan M, Jayakumar R; (2014) Chitin and chitosan in selected biomedical applications. Progress in Polymer Science 39,1644-1647, DOI:10.1016 j. progpolymsci.2014.02.008
  • [9] Szcześniak M, Pluta J; (2013) The effect of selected excipients on properties hydrogels on the basis Carbopol 934 P. Polim Med 43, 29-34.
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-000db229-adae-4daa-848b-501bc3d4dc32
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.