The paper presents the results of a study involving the impact of sudden change of crosssectional area on the flow patterns and local pressure drops for flow of multi-phase mixture. The experiment was conducted in the conditions of a horizontal and vertical flow through a measuring channel. Pressure drops calculated on the basis Kawahara and Lottes methods are compared with experimental data. A system of two interconnected pipes with internal diameters of 40 and 22 mm as well as 46 and 16 mm and a total length of 7 m formed the measurement channel. The experiments involved air, water and oil.