In the paper the method of automatic control of the two stage hybrid sorption-compression refrigeration system for different ambient conditions is presented. The main advantages of the system are its environmental friendly working fluids and waste or renewable low temperature heat source utilization. The control algorithm is designed for operation in four seasons’ conditions. During cold seasons the heat from the second stage condenser, as waste heat, may be used to increase the temperature of the heat pump source. The system is composed of dependent subsystems with individual controls, however it is controlled by the computer program as master control. The issues related to the optimization of operation of the refrigeration system, taking into account the maximum usage of available renewable or waste heat sources, are discussed in the paper.