In this study the results of numerical simulations of hydrodynamics in an agitated vessel with eccentrically located impeller (HE3 or propeller) are presented. Mathematical model of the velocity field is based on Navier-Stocks equation. Characteristics of turbulent flow of liquid is described with the use of CFD methods. In this work the Scale Adaptive Simulation approach coupled with Sliding Mesh method is used. The time-dependent simulations were carried out with ANSYS 14 CFX software.