Executive dysfunction profile in mesial temporal lobe epilepsy

• Authors: Agnieszka Olejnik , Aleksandra Bala , Tomasz Dziedzic , Andrzej Rysz , Andrzej Marchel , Przemysław Kunert

Abstracts

EN

The aim of the study was a comprehensive assessment of the profile of executive dysfunctions in patients with MTLE and the search for associations between the results of neuropsychological tests and individual clinical variables. We examined 25 patients with MTLE and 25 healthy controls using the Montreal Cognitive Assessment (MoCA), Color Trails Test (CTT), Tower of London (ToL), Victoria Stroop Test (VLT) and Wisconsin Card Sorting Test (WCST). We considered the possible effects of seizure frequency and lateralization of the epileptogenic zone on various aspects of cognitive functioning. MTLE group scored significantly lower than controls in MoCA (p = 0.000) and needed significantly more time (p=0.000) in CTT-2. They also had lower scores in several parts of ToL (total correct, p=0.004; additional moves, p=0.038; execution time, p=0.001; problem-solving time, p=0.003) and WCST (error responses, p=0.003; conceptual level responses, p=0.000; completed categories, p=0.007; perseverative responses, p=0.004; perseverative errors, p=0.009). There were no significant differences between the clinical and control group in VST and in other indicators of CTT, ToL and WCST. Neither the laterality of the epileptogenic focus nor the seizure frequency were significantly correlated with the results. Patients with MTLE exhibit a wide range of executive dysfunctions. Importantly, the disorders were present only in some aspects of functioning, such as: logical reasoning, planning, switching between tasks, cognitive flexibility and problem-solving, while others e.g. inhibition, remained normal. Our results constitute a significant enrichment of knowledge concerning the specificity of functioning of this group of patients which may help clinicians to introduce solutions to improve the functioning of these patients.

Keywords

EN

MTLE; executive functions; cognitive disorders; cognitive functioning

• Publisher: Fundacja Edukacji Medycznej, Promocji Zdrowia, Sztuki i Kultury Ars Medica
• Journal: Acta Neuropsychologica
• Year: 2023
• Volume: 22(1)
• Pages: 1-13

Dates

published

2024

Contributors

author

Agnieszka Olejnik

• Faculty of Psychology, University of Warsaw, Warsaw, Poland

author

Aleksandra Bala

• Faculty of Psychology, University of Warsaw, Warsaw, Poland

author

Tomasz Dziedzic

• Department of Neurosurgery, Medical University of Warsaw, Warsaw, Poland

author

Andrzej Rysz

• Department of Neurosurgery, Medical University of Warsaw, Warsaw, Poland

author

Andrzej Marchel

• Department of Neurosurgery, Medical University of Warsaw, Warsaw, Poland

author

Przemysław Kunert

• Department of Neurosurgery, Medical University of Warsaw, Warsaw, Poland

Identifiers

DOI

10.5604/01.3001.0053.9737

Biblioteka Nauki

28762847