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2022 | 76 | 6 | 37-44

Article title

Intraoperative margins in oral and oropharyngeal cancer transoral surgery – benefit from sampling method modifications.

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Abstracts

EN
Objectives: To investigate the impact on local relapse rate (LRR) and disease specific survival (DSS) of intraoperative margins (FS) obtained by circumferential sampling method, corresponding to the lesion shape and marked using clock-face orientation combined with narrow band imaging (NBI) in head and neck squamous cell carcinoma Materials and Methods: 147 consecutive patients who underwent primary surgery with radical intent for oral and oropharyngeal cancer between 2011 and 2016 were prospectively enrolled. Patients were assigned to 3 groups with different sampling methods. In group A (n=44) a classical FS sampling method was used. In group B (n=73), the clock-face orientation sampling method (FS o’clock) was used, whereas in group C (n=30), the FS o’clock method combined with NBI. The primary outcome measure was the interdependence between FS sampling methods and oncological outcomes measured by LRR and DSS. Results: In total, 1534 FS samples were obtained with range of 3-24 FS taken per case, median 7.25 in group A, 8.15 in group B and 7.52 in group C. When compared FS histology and final histology in all groups the sensitivity, specificity and accuracy were 61.54%, 98.51% and 95.24%, respectively. The overall LRR equaled 8.8%. The lowest LRR was observed in FS o’clock method combined with NBI (6.67%) followed by FS o’clock (6.85%) and FS classic (13.64%). For all patients, DSS achieved 95.92% - 95.45% in FS classic, 95.89% in FS o’clock and 96.67%. in FS o’clock combined with NBI. Conclusion: The FS o’clock sampling method combined with NBI increases the chance of achieving tumor-negative margins and in result improves the treatment outcome reflected by LRR and DSS.

Year

Volume

76

Issue

6

Pages

37-44

Physical description

Dates

published
2022

Contributors

author
  • Regional Specialist Hospital Wroclaw, Research & Development Centre, Poland
  • Department of Otolaryngology, Ludwik Rydygier Memorial Specialized Hospital in Krakow, Krakow, Poland
  • Department of Otolaryngology, Ludwik Rydygier Memorial Specialized Hospital in Krakow, Krakow, Poland
  • Poznan University of Medical Sciences, Poznan, Poland
  • Poznan University of Medical Sciences, Poznan, Poland
  • Regional Specialist Hospital Wroclaw, Research & Development Centre, Poland
  • lnstitute of Human Genetics, Polish Academy of Sciences, Poznan, Poland

References

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Document Type

Publication order reference

Identifiers

Biblioteka Nauki
58463949

YADDA identifier

bwmeta1.element.ojs-doi-10_5604_01_3001_0015_9678
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