Intraoperative margins in oral and oropharyngeal cancer transoral surgery – benefit from sampling method modifications.

• Authors: Hanna Klimza , Grażyna Greczka , Leszek Grabowski , Przemyslaw Majewski , Jacek Banaszewski , Małgorzata Wierzbicka

Abstracts

EN

Objectives: To investigate the impact on local relapse rate (LRR) and disease specific survival (DSS) of intraoperative margins (FS) obtained by circumferential sampling method, corresponding to the lesion shape and marked using clock-face orientation combined with narrow band imaging (NBI) in head and neck squamous cell carcinoma Materials and Methods: 147 consecutive patients who underwent primary surgery with radical intent for oral and oropharyngeal cancer between 2011 and 2016 were prospectively enrolled. Patients were assigned to 3 groups with different sampling methods. In group A (n=44) a classical FS sampling method was used. In group B (n=73), the clock-face orientation sampling method (FS o’clock) was used, whereas in group C (n=30), the FS o’clock method combined with NBI. The primary outcome measure was the interdependence between FS sampling methods and oncological outcomes measured by LRR and DSS. Results: In total, 1534 FS samples were obtained with range of 3-24 FS taken per case, median 7.25 in group A, 8.15 in group B and 7.52 in group C. When compared FS histology and final histology in all groups the sensitivity, specificity and accuracy were 61.54%, 98.51% and 95.24%, respectively. The overall LRR equaled 8.8%. The lowest LRR was observed in FS o’clock method combined with NBI (6.67%) followed by FS o’clock (6.85%) and FS classic (13.64%). For all patients, DSS achieved 95.92% - 95.45% in FS classic, 95.89% in FS o’clock and 96.67%. in FS o’clock combined with NBI. Conclusion: The FS o’clock sampling method combined with NBI increases the chance of achieving tumor-negative margins and in result improves the treatment outcome reflected by LRR and DSS.

Keywords

EN

intraoperative margins; frozen section; trans-oral resection; oral cancer; oropharyngeal cancer; NBI

• Publisher: Index Copernicus International
• Journal: Polish Journal of Otolaryngology
• Year: 2022
• Volume: 76
• Issue: 6
• Pages: 37-44

Dates

published

2022

Contributors

author

Hanna Klimza

• Regional Specialist Hospital Wroclaw, Research & Development Centre, Poland

author

Grażyna Greczka

• Department of Otolaryngology, Ludwik Rydygier Memorial Specialized Hospital in Krakow, Krakow, Poland

• https://orcid.org/0000000196910866

author

Leszek Grabowski

• Department of Otolaryngology, Ludwik Rydygier Memorial Specialized Hospital in Krakow, Krakow, Poland

author

Przemyslaw Majewski

• Poznan University of Medical Sciences, Poznan, Poland

author

Jacek Banaszewski

• Poznan University of Medical Sciences, Poznan, Poland

• https://orcid.org/0000000219175738

author

Małgorzata Wierzbicka

• Regional Specialist Hospital Wroclaw, Research & Development Centre, Poland
• lnstitute of Human Genetics, Polish Academy of Sciences, Poznan, Poland

• https://orcid.org/0000000300066352

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Identifiers

DOI

10.5604/01.3001.0015.9678

Biblioteka Nauki

58463949