A randomized, double-blind, placebo-controlled study to investigate the use of bacteriophages in patients with chronic rhinosinusitis with nasal polyps

• Authors: Konstantin Grigorievich Dobretsov , Oxana Kolenchukova , Alexander Sipkin , Luisa Maria Bellussi , Giorgio Ciprandi , Desiderio Passali

Abstracts

EN

Introduction: A randomized, double-blind, placebo-controlled study investigates the use of bacteriophages in the treatment of chronic rhinosinusitis with nasal polyps.
Material and methods: 40 adult patients with chronic rhinosinusitis with nasal polyps were examined. All patients underwent functional endoscopic sinus surgery. After the surgery, 20 patients were administered an intranasal gel with bacteriophage mixture (Otofag, Micromir, Russia) twice a day for ten weeks, while 20 other patients received a placebo solution.
Results: On the 10th day, IL-1β secretion diminished (63 mg/ml versus 440 mg/ml in control). There was a decrease in the total number of microorganisms and Enterobacteriaceae (5.7 x 10⁶ CFU/ml versus 1.2 x 10⁹ CFU/ml in the control group) and the absence of Streptococci (versus 2.1 x 10⁹ CFU/ml in control) was noted on the 30th day of treatment in the group receiving bacteriophage mixture. On the 10th day, a decrease in the activity of secretory IL-1β and IL-8 strongly and very strongly correlated with a total number of microorganisms (r = 0.7; r = 0.9, respectively), as well as a decrease in the activity of secretory IL-8 correlated with the number of Enterobacteriaceae (r = 0.72) and Staphylococci (r = 0.65) in the experimental group treated with bacteriophages. On the 30th day, the decrease in serum IL-1β significantly correlated with the total number of microorganisms (r = 0.80) and Enterobacteriaceae (r = 0.90) in the experimental group.
Conclusions: The administration of bacteriophages restored the balance of microorganisms in the nasal cavity and decreased inflammatory response in chronic rhinosinusitis with nasal polyps. Changes such as an inflammation dampening could potentially contribute to reducing recurrent growth of polyp tissue in the future.

Keywords

EN

bacteria; bacteriophages; chronic rhinosinusitis with nasal polyps; cytokines; local treatment

• Publisher: Index Copernicus International
• Journal: Polish Journal of Otolaryngology
• Year: 2021
• Volume: 75
• Issue: 6
• Pages: 33-37

Dates

published

2021

Contributors

author

Konstantin Grigorievich Dobretsov

• Sokolov’ Hospital N 122 оf the Federal Medical-Biological Agency of Russia, Krasnoyarsk, Russia

author

Oxana Kolenchukova

• Federal Siberian Scientific and Clinical Center of Federal Medical-Biological Agency of Russia, Krasnoyarsk, Russia

author

Alexander Sipkin

• Federal Research Center “Krasnoyarskii Scientific Center” of the Siberian branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North, Russia

author

Luisa Maria Bellussi

• IFOS, International Federation of Otorhinolaryngological Societies, Rome, Italy

author

Giorgio Ciprandi

• Outpatients Clinics Dept., Casa di Cura Villa Montallegro, Genoa, Italy

author

Desiderio Passali

• IFOS, International Federation of Otorhinolaryngological Societies, Rome, Italy

Identifiers

DOI

10.5604/01.3001.0015.0084

Biblioteka Nauki

23203235