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2017 | 56 | 3 | 139-147

Article title

Actinomycin D as an Epimutagen in Protists

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Abstracts

EN
A previously unrecorded property of actinomycin D, a well-known antibiotic, was discovered in the course of long-term genetic research on the amoeba Amoeba proteus and the ciliate Dileptus anser. In these protists actinomycin D can induce an unusual type of hereditary variation, which we refer to as the inheritable destabilization of characters. A number of features indicate that this variation is epigenetic, that is, not caused by mutations in the DNA. Therefore, actinomycin D may be considered as an inducer of epigenetic inheritable changes, in other words, as an epimutagen.

Year

Volume

56

Issue

3

Pages

139-147

Physical description

Dates

published
2017

Contributors

  • Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia
  • Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia

References

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Document Type

Publication order reference

Identifiers

Biblioteka Nauki
52376322

YADDA identifier

bwmeta1.element.ojs-doi-10_4467_16890027AP_17_012_7493
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