Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl

PL EN


Preferences help
enabled [disable] Abstract
Number of results
2024 | 7 | 2 | 1-11

Article title

Predictive capacity of vitamin D and HDL levels alone and in combination for mortality in critically ill patients

Content

Title variants

Languages of publication

Abstracts

EN
INTRODUCTION: Vitamin D and HDL (high density lipoprotein) levels have potential to be used as an early and simple predictor of morbidity and mortality in critically ill patients. The aim of the study was to determine the predictive capacity of vitamin D and HDL levels alone and in combination for mortality in critically ill patients. MATERIALS AND METHODS: Prospective observational study involving 302 patients admitted to an intensive care unit (ICU). Blood samples were obtained within the initial 24 hours of admission to assess vitamin D and HDL levels. Vitamin D levels of >20 ng/ml were considered non-deficient and ≤ 20 ng/mL considered deficient. HDL levels >30 mg/dl were considered normal HDL and <30 mg / dl were considered low HDL. The study collected data on various parameters including the APACHE II score at the ICU admission, SOFA scores throughout the ICU stay, 28-day mortality, as well as the requirement for mechanical ventilation, inotropic support, and renal replacement therapy RESULTS: Of 302 patients, 102 (33.77%) had mortality in 28 days. While analysing the predictive capacity of vitamin D and HDL alone and in combination for mortality at 28 days, the AUC (Area Under the Curve) was 0.667 (95% CI 0.610 TO 0.720), 0.673 (95%CI 0.617 TO 0.725), 0.628 (95% CI 0.571 TO 0.683) respectively. The vitamin D level 12 ng/ml and the HDL level 29 mg/dl were found to have a statistically significant association with mortality. P value <0.001. CONCLUSIONS: The study showed that vitamin D and HDL levels alone and in combination have a significant association with mortality in critically ill patients.

Year

Volume

7

Issue

2

Pages

1-11

Physical description

Dates

published
2024

Contributors

author
  • Department of Critical Care Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Dr RML Hospital, New Delhi, India
author
  • Department of Critical Care Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Dr RML Hospital, New Delhi, India
author
  • Department of Anesthesiology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr RML Hospital, New Delhi, India
  • Department of Critical Care Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Dr RML Hospital, New Delhi, India
author
  • Department of Critical Care Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Dr RML Hospital, New Delhi, India
author
  • Department of Critical Care and Emergency Medicine, Sir Gangaram Hospital, New Delhi, India
author
  • Department of Critical Care Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Dr RML Hospital, New Delhi, India

References

  • Weigl W, Adamski J, Goryński P, Kański A, Hultström M. ICU mortality and variables associated with ICU survival in Poland: A nationwide database study. Eur J Anaesthesiol. 2018; 35(12): 949-954. doi: https://doi.org/10.1097/EJA.0000000000000889
  • Awad A, Bader-El-Den M, McNicholas J, Briggs J, El-Sonbaty Y. Predicting hospital mortality for intensive care unit patients: Time-series analysis. Health Informatics J. 2020; 26(2): 1043-1059. doi: https://doi.org/10.1177/1460458219850323
  • Moraes RB, Friedman G, Wawrzeniak IC, Marques LS, Nagel FM, Lisboa TC, et al. Vitamin D deficiency is independently associated with mortality among critically ill patients. Clinics (Sao Paulo) 2015; 70(5): 326-332. doi: https://doi.org/10.6061/clinics/2015(05)04
  • Amrein K, Litonjua AA, Moromizato T, Quraishi SA, Gibbons FK, Pieber TR, et al. Increases in prehospitalization serum 25(OH)D concentrations are associated with improved 30-day mortality after hospital admission: A cohort study. Clin Nutr. 2016; 35(2): 514-521. doi: https://doi.org/10.1016/j.clnu.2015.03.020
  • Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr. 2004; 80(6 Suppl): 1678S-88S. doi: https://doi.org/10.1093/ajcn/80.6.1678S www.criticalcareinnovations.eu doi:10.32114/CCI.2024.7.2.1.11
  • Matthews LR, Ahmed Y, Wilson KL, Griggs DD, Danner OK. Worsening severity of vitamin D deficiency is associated with increased length of stay, surgical intensive care unit cost, and mortality rate in surgical intensive care unit patients. Am J Surg. 2012; 204(1): 37-43. doi: https://doi.org/10.1016/j.amjsurg.2011.07.021
  • Hansdottir S, Monick MM, Hinde SL, Lovan N, Look DC, Hunninghake GW. Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense. J Immunol. 2008; 181(10): 7090-7099. doi: https://doi.org/10.4049/jimmunol.181.10.7090
  • Zhong GC, Huang SQ, Peng Y, Wan L, Wu YQ, Hu TY, et al. HDL-C is associated with mortality from all causes, cardiovascular disease and cancer in a J-shaped dose-response fashion: a pooled analysis of 37 prospective cohort studies. Eur J Prev Cardiol. 2020; 27(11): 1187-1203. doi: https://doi.org/10.1177/2047487320914756
  • Alkhatatbeh MJ, Amara NA, Abdul-Razzak KK. Association of 25-hydroxyvitamin D with HDL-cholesterol and other cardiovascular risk biomarkers in subjects with non-cardiac chest pain. Lipids Health Dis. 2019; 18(1): doi: https://doi.org/10.1186/s12944-019-0961-3
  • Derakhshanian H, Rastad H, Ghosh S, Zeinali M, Ziaee M, Khoeini T, et al. The predictive power of serum vitamin D for poor outcomes in COVID-19 patients. Food Sci Nutr. 2021; 9(11): 6307-6313. doi: https://doi.org/10.1002/fsn3.2591
  • Lee SH, Park MS, Park BH, Jung WJ, Lee IS, Kim SY, et al. Prognostic Implications of Serum Lipid Metabolism over Time during Sepsis. Biomed Res Int. 2015; 2015: 789298. doi: https://doi.org/10.1155/2015/789298
  • Venkatram S, Chilimuri S, Adrish M, Salako A, Patel M, Diaz-Fuentes G. Vitamin D deficiency is associated with mortality in the medical intensive care unit. Crit Care. 2011; 15(6): R292. doi: https://doi.org/10.1186/cc10585
  • Remmelts HH, van de Garde EM, Meijvis SC, Peelen EL, Damoiseaux JG, Grutters JC, et al. Addition of vitamin D status to prognostic scores improves the prediction of outcome in community-acquired pneumonia. Clin Infect Dis. 2012; 55(11): 1488-1494. doi: https://doi.org/10.1093/cid/cis751
  • Lange N, Litonjua AA, Gibbons FK, Giovannucci E, Christopher KB. Pre-hospital vitamin D concentration, mortality, and bloodstream infection in a hospitalized patient population. Am J Med. 2013; 126(7): 640.e19-27. doi: https://doi.org/10.1016/j.amjmed.2012.12.014
  • Cirstea M, Walley KR, Russell JA, Brunham LR, Genga KR, Boyd JH. Decreased high-density lipoprotein cholesterol level is an early prognostic marker for organ dysfunction and death in patients with suspected sepsis. J Crit Care. 2017; 38: 289-294. doi: https://doi.org/10.1016/j.jcrc.2016.11.041
  • Mørland JG, Magnus P, Vollset SE, Leon DA, Selmer R, Tverdal A. Associations between serum high-density lipoprotein cholesterol levels and cause-specific mortality in a general population of 345 000 men and women aged 20-79 years. Int J Epidemiol. 2023; 52(4): 1257-1267. doi: https://doi.org/10.1093/ije/dyad011
  • Tanaka S, Couret D, Tran-Dinh A, Duranteau J, Montravers P, Schwendeman A, et al. High-density lipoproteins during sepsis: from bench to bedside. Crit Care. 2020; 24(1): 134. doi: https://doi.org/10.1186/s13054-020-02860-3
  • Elmi C, Fan MM, Le M, Cheng G, Khalighi K. Association of serum 25-Hydroxy Vitamin D level with lipid, lipoprotein, and apolipoprotein level. J Community Hosp Intern Med Perspect. 2021; 11(6): 812-816. doi: https://doi.org/10.1080/20009666.2021.1968571
  • Vassiliou AG, Jahaj E, Pratikaki M, Orfanos SE, Dimopoulou I, Kotanidou A. Low 25-Hydroxyvitamin D Levels on Admission to the Intensive Care Unit May Predispose COVID-19 Pneumonia Patients to a Higher 28-Day Mortality Risk: A Pilot Study on a Greek ICU Cohort. Nutrients 2020; 12(12): 3773. doi: https://doi.org/10.3390/nu12123773 www.criticalcareinnovations.eu doi:10.32114/CCI.2024.7.2.1.11
  • Tanaka S, Labreuche J, Drumez E, Harrois A, Hamada S, Vigué B, et al. Low HDL levels in sepsis versus trauma patients in intensive care unit. Ann Intensive Care. 2017; 7: 60. doi: https://doi.org/10.1186/s13613-017-0284-3
  • Zapatero A, Dot I, Diaz Y, Gracia MP, Pérez-Terán P, Climent C, et al. Severe vitamin D deficiency upon admission in critically ill patients is related to acute kidney injury and a poor prognosis. Med Intensiva (Engl Ed). 2018; 42(4): 216-224. doi: https://doi.org/10.1016/j.medin.2017.07.004
  • Shen H, Mei Y, Zhang K, Xu X. The Effect of Vitamin D Supplementation on Clinical Outcomes for Critically Ill Patients: A Systemic Review and Meta-Analysis of Randomized Clinical Trials. Front Nutr. 2021; 8: 664940. doi: https://doi.org/10.3389/fnut.2021.664940
  • Roveran Genga K, Lo C, Cirstea M, Zhou G, Walley KR, Russell JA, et al.. Two-year follow-up of patients with septic shock presenting with low HDL: the effect upon acute kidney injury, death and estimated glomerular filtration rate. J Intern Med. 2017; 281(5): 518-529. doi: https://doi.org/10.1111/joim.12601
  • Loni R, Zameer S, Hasan FA, Abbas I, Mesrati H, George J, et al. Vitamin-D Status and Clinical Outcomes in Critically Ill Children. Indian J Crit Care Med. 2023; 27(7): 503-509. doi: https://doi.org/10.5005/jp-journals-10071-24486

Document Type

Publication order reference

Identifiers

Biblioteka Nauki
55783635

YADDA identifier

bwmeta1.element.ojs-doi-10_32114_CCI_2024_7_2_1_11
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.