Predictive capacity of vitamin D and HDL levels alone and in combination for mortality in critically ill patients

• Authors: Kuldeep Singh , Amlendu Yadav , Rupesh Yadav , Damera Seshi Kumar , Ankit Purohit , Komal Dahiya , Praveen Kumar

Abstracts

EN

INTRODUCTION: Vitamin D and HDL (high density lipoprotein) levels have potential to be used as an early and simple predictor of morbidity and mortality in critically ill patients. The aim of the study was to determine the predictive capacity of vitamin D and HDL levels alone and in combination for mortality in critically ill patients. MATERIALS AND METHODS: Prospective observational study involving 302 patients admitted to an intensive care unit (ICU). Blood samples were obtained within the initial 24 hours of admission to assess vitamin D and HDL levels. Vitamin D levels of >20 ng/ml were considered non-deficient and ≤ 20 ng/mL considered deficient. HDL levels >30 mg/dl were considered normal HDL and <30 mg / dl were considered low HDL. The study collected data on various parameters including the APACHE II score at the ICU admission, SOFA scores throughout the ICU stay, 28-day mortality, as well as the requirement for mechanical ventilation, inotropic support, and renal replacement therapy RESULTS: Of 302 patients, 102 (33.77%) had mortality in 28 days. While analysing the predictive capacity of vitamin D and HDL alone and in combination for mortality at 28 days, the AUC (Area Under the Curve) was 0.667 (95% CI 0.610 TO 0.720), 0.673 (95%CI 0.617 TO 0.725), 0.628 (95% CI 0.571 TO 0.683) respectively. The vitamin D level 12 ng/ml and the HDL level 29 mg/dl were found to have a statistically significant association with mortality. P value <0.001. CONCLUSIONS: The study showed that vitamin D and HDL levels alone and in combination have a significant association with mortality in critically ill patients.

Keywords

EN

Intensive care unit; high-density lipoprotein; mortality; vitamin D

• Publisher: Towarzystwo Pomocy Doraźnej
• Journal: Critical Care Innovations
• Year: 2024
• Volume: 7
• Issue: 2
• Pages: 1-11

Dates

published

2024

Contributors

author

Kuldeep Singh

• Department of Critical Care Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Dr RML Hospital, New Delhi, India

• https://orcid.org/0000000339607179

author

Amlendu Yadav

• Department of Critical Care Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Dr RML Hospital, New Delhi, India

• https://orcid.org/0000000336711587

author

Rupesh Yadav

• Department of Anesthesiology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr RML Hospital, New Delhi, India

• https://orcid.org/0000000263796101

author

Damera Seshi Kumar

• Department of Critical Care Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Dr RML Hospital, New Delhi, India

• https://orcid.org/0000000334392244

author

Ankit Purohit

• Department of Critical Care Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Dr RML Hospital, New Delhi, India

• https://orcid.org/0009000762220016

author

Komal Dahiya

• Department of Critical Care and Emergency Medicine, Sir Gangaram Hospital, New Delhi, India

• https://orcid.org/0009000616208449

author

Praveen Kumar

• Department of Critical Care Medicine, Atal Bihari Vajpayee Institute of Medical Sciences and Dr RML Hospital, New Delhi, India

• https://orcid.org/0009000564326397

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Identifiers

DOI

10.32114/CCI.2024.7.2.1.11

Biblioteka Nauki

55783635