Endothelial function/damage markers and NGAL – intraoperative assessment in blood specimens obtained from different sampling sites during open repair of abdominal aortic aneurysm

• Authors: Michał Kokot , Grzegorz Biolik , Anna Kokot , Leszek Kędzierski , Tadeusz Fojt , Damian Ziaja , Krzysztof Ziaja , Jan Duława

Title variants

PL

Śródoperacyjne stężenia wskaźników czynności/uszkodzenia śródbłonka oraz NGAL oznaczanych w próbkach krwi pochodzących z różnych źródeł naczyniowych w trakcie zabiegu naprawczego tętniaka aorty brzusznej metodą otwartą

• Languages of publication: EN PL

Abstracts

EN

WPROWADZENIE: Celem pracy było zbadanie dynamiki zmian stężenia lipokainy związanej z żelatynazą neutrofilów (neutrophil gelatinase-associated lipocalin – NGAL), która jest wskaźnikiem ostrego uszkodzenia nerek, oraz wskaźników czynności/uszkodzenia śródbłonka: selektyny P, cząsteczki adhezji międzykomórko-wej 1 (intercellular adhesion molecule 1 – ICAM-1), cząstki adhezyjnej śródbłonka naczyniowego 1 (vascular cell adhesion molecule 1 – VCAM-1) i czynnika von Willebranda (von Willebrand factor – vWf) w próbkach krwi pobieranych z różnych obszarów naczyniowych podczas elektywnej operacji naprawczej tętniaka aorty brzusznej (abdominal aortic aneurysm – AAA) metodą otwartą. MATERIAŁ I METODY: Badanie objęło grupę 33 chorych zakwalifikowanych do planowego zabiegu metodą otwartą (open repair – ORe). Wszystkie wymienione parametry oznaczono w próbkach krwi pobranych: 1) przed zabiegiem z żyły łokciowej oraz w trakcie zabiegu; 2) z żyły nerkowej przed założeniem zacisku aorty; 3) z żyły nerkowej bezpośrednio przed zwolnieniem zacisku aorty; 4) z żyły łokciowej bezpośrednio przed zwolnieniem zacisku aorty; 5) z żyły głównej dolnej bezpośrednio przed zwolnieniem zacisku aorty; 6) z żyły nerkowej w 5 minucie po zwolnieniu zacisku aorty; 7) z żyły łokciowej w 5 minucie po zwolnieniu zacisku aorty. WYNIKI: Stwierdzono zmniejszenie stężenia selektyny P, ICAM-1 i VCAM-1 w próbkach pobranych z żyły łokciowej bezpośrednio przed zdjęciem zacisku aorty oraz 5 minut po zdjęciu zacisku aorty w porównaniu z wartościami przed zabiegiem. Ponadto obserwowano nagłe zmiany stężenia NGAL, vWf i VCAM-1 podczas zabiegu. WNIOSKI: Uzyskane wyniki wydają się przemawiać za rozwojem stanu zapalnego już w trakcie zabiegu operacyjnego AAA metodą otwartą.

PL

INTRODUCTION: The aim of the study was to investigate the dynamics of changes in the concentrations of neutrophil gelatinase-associated lipocalin (NGAL), an acute kidney injury biomarker, as well as endothelial function/damage markers including P-selectin, intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and the von Willebrand factor (vWf) in blood specimens obtained from different sampling sites during open abdominal aortic aneurysm (AAA) repair. MATERIAL AND METHODS: Thirty-three patients qualified for elective open repair (ORe) were enrolled in the study. All the mentioned parameters were determined in blood samples drawn from: 1) the cubital vein prior to surgery, and then intraoperatively, 2) the renal vein before aortic cross-clamping, 3) renal vein immediately before aortic cross-clamp removal, 4) cubital vein immediately before aortic cross-clamp removal, 5) inferior vena cava immediately before aortic cross-clamp removal, 6) renal vein at 5 minutes after aortic cross-clamp removal and 7) cubital vein at 5 minutes after aortic cross-clamp removal. RESULTS: The P-selectin, ICAM-1 and VCAM-1 concentrations were found to have decreased in the cubital samples drawn immediately before aortic clamp removal and at 5 minutes after aortic clamp removal vs the pre-surgery cubital samples. Rapid changes during surgery were also found in the NGAL, vWf and VCAM-1 concentrations. CONCLUSIONS: The obtained results seem to evidence the development of an inflammatory response while open AAA repair is still in progress.

Keywords

EN

ICAM-1; NGAL; P-selectin; VCAM-1; abdominal aortic aneurysm

Discipline

• MEDICINE: MEDICINE

• Publisher: Śląski Uniwersytet Medyczny w Katowicach
• Journal: Annales Academiae Medicae Silesiensis
• Year: 2025
• Volume: 79
• Pages: 45-55

Dates

published

2025

Contributors

author

Michał Kokot

• Department of Internal Medicine and Metabolic Diseases, Faculty of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland

author

Grzegorz Biolik

• Department of General and Vascular Surgery, Angiology and Phlebology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland

author

Anna Kokot

• Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland

author

Leszek Kędzierski

• Department of Internal Medicine and Metabolic Diseases, Faculty of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland

author

Tadeusz Fojt

• Department of Internal Medicine and Metabolic Diseases, Faculty of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland

author

Damian Ziaja

• Department of General and Vascular Surgery, Angiology and Phlebology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland

author

Krzysztof Ziaja

• Department of General and Vascular Surgery, Angiology and Phlebology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland

author

Jan Duława

• Department of Internal Medicine and Metabolic Diseases, Faculty of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland

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• Document Type: article

Identifiers

DOI

10.18794/aams/199671

Biblioteka Nauki

58843074