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Number of results
2024 | 46 | 45-51

Article title

Effect of Supervised Physical Exercise on Oxidative Stress in Children with Autism

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Abstracts

EN
Background: The etiology of autism spectrum disorders is not well known but oxidative stress has been suggested to play a pathological role. Purpose: The present study aimed to investigate the effects of supervised physical exercise on oxidative stress in children with autism. Methods: Thirty boys with autism (7 to 9 years old) voluntarily participated in this study. They were randomly divided into experimental and control groups. The experimental group performed a physical curriculum known as sports, play and active recreation for kids (SPARK) for 12 weeks (3 sessions of 45 minutes per week), while the control group was exempted to participate in the program. As the clinical parameters, the level of brain-derived neurotrophic factor (BDNF) and malondialdehyde (MDA) were measured before and after the intervention. Results: The results indicated that BDNF levels significantly increased (85.7 %) and MDA concentration significantly decreased (29.2%) in the experimental group (p < 0.05). Conclusions: In conclusion, the supervised physical exercise may result in less oxidative stress in children with autism.

Contributors

  • Department of Physical Education, Shiraz branch, Islamic Azad University, Shiraz, Iran
author
  • Department of Physical Education, Shiraz branch, Islamic Azad University, Shiraz, Iran
  • Faculty of Sport Sciences‚ Bu-Ali Sina University‚ Hamedan‚ Iran
author
  • Faculty of Physical Education and Sport Sciences‚ Kharazmi University‚ Tehran‚ Iran
  • Department of Exercise Physiology, Faculty of Physical Education and Sport Science, University of Guilan, Rasht, Iran

References

  • Al-Ayadhi, L. Y. (2012). Relationship between Sonic hedgehog protein, brain-derived neurotrophic factor and oxidative stress in autism spectrum disorders. Neurochemical research, 37, 394–400. https://doi.org/10.1007/s11064-011-0624-x
  • Autism Prevalence Higher, According to Data from 11 ADDM Communities. (2023, March 23, 2023). https://www.cdc.gov/media/releases/2023/p0323-autism.html
  • Barbosa, A. G., Pratesi, R., Paz, G. S. C., Dos Santos, M. A. A. L., Uenishi, R. H., Nakano, E. Y., . . . Pratesi, C. B. (2020). Assessment of BDNF serum levels as a diagnostic marker in children with autism spectrum disorder. Scientific Reports, 10(1), 17348. https://doi.org/10.1038/s41598-020-74239-x
  • Chauhan, A., Chauhan, V., Brown, W. T., & Cohen, I. (2004). Oxidative stress in autism: Increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin-the antioxidant proteins. Life sciences, 75(21), 2539–2549.
  • de Assis, G. G., & Gasanov, E. V. (2019). BDNF and cortisol integrative system–plasticity vs. degeneration: implications of the Val66Metpolymorphism. Frontiers in Neuroendocrinology, 55, 100784.
  • Ennezat, P. V., Malendowicz, S. L., Testa, M., Colombo, P. C., Cohen-Solal, A., Evans, T., & LeJemtel, T. H. (2001). Physical training in patients with chronic heart failure enhances the expression of genes encoding antioxidative enzymes. Journal of the American College of Cardiology, 38(1), 194–198.
  • Ghezzo, A., Visconti, P., Abruzzo, P. M., Bolotta, A., Ferreri, C., Gobbi, G., . . . Nanetti, L. (2013). Oxidative stress and erythrocyte membrane alterations in children with autism: correlation with clinical features. PLoS One, 8(6), e66418.
  • Gomez-Pinilla, F., Zhuang, Y., Feng, J., Ying, Z., & Fan, G. (2011). Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation. European Journal of Neuroscience, 33(3), 383–390.
  • Han, Y. M., Yau, S.-Y., Chan, M. M., Wong, C.-K., & Chan, A. S. (2022). Altered cytokine and Bdnf levels in individuals with autism spectrum disorders. Brain Sciences, 12(4), 460.
  • Liu, X., Lin, J., Zhang, H., Khan, N. U., Zhang, J., Tang, X., . . . Shen, L. (2022). Oxidative Stress in Autism Spectrum Disorder-Current Progress of Mechanisms and Biomarkers. Frontiers in psychiatry, 13, 813304.
  • Liu, Z., Guo, M., Gao, Y., & Jiang, X. (2020). Research progress on the relationship between BDNF, the polymorphysis of its gene, and childhood autism. World Journal of Neuroscience, 10(02), 107.
  • McKenzie, T. L., Sallis, J. F., Rosengard, P., & Ballard, K. (2016). The SPARK programs: a public health model of physical education research and dissemination. Journal of Teaching in Physical Education, 35(4), 381–389.
  • Mirzavandi, F., Sabet, N., Aminzadeh, A., Heidari, M., Pouya, F., Moslemizadeh, A., . . . Bashiri, H. (2023). Effects of varied‑intensity endurance exercise training on oxidative and antioxidant factors in the liver of rats with valproic acid‑induced autism. Acta Neurobiologiae Experimentalis, 83(1), 25–33.
  • Sabet, N., Soltani, Z., & Khaksari, M. (2022). The effects of exercise on kidney injury: the role of SIRT1. Molecular Biology Reports, 49(5), 4025–4038.
  • Shen, L., Liu, X., Zhang, H., Lin, J., Feng, C., & Iqbal, J. (2020). Biomarkers in autism spectrum disorders: Current progress. Clinica Chimica Acta, 502, 41–54.
  • Skogstrand, K., Hagen, C. M., Borbye-Lorenzen, N., Christiansen, M., Bybjerg-Grauholm, J., Bækvad-Hansen, M., . . . Nordentoft, M. (2019). Reduced neonatal brain-derived neurotrophic factor is associated with autism spectrum disorders. Translational psychiatry, 9(1), 252.
  • Zaki, M., El-Bassyouni, H. T., Hamed, K., Moustafa, R. S. I., & Youness, E. R. (2022). Brain derived neurotrophic factor, oxidative stress status and vitamin D levels in patients with autism spectrum disorder. New Zealand Journal of Medical Laboratory Science, 76(1), 10–13.
  • Zhang, J., Li, X., Shen, L., Khan, N. U., Zhang, X., Chen, L., . . . Luo, P. (2021). Trace elements in children with autism spectrum disorder: a meta-analysis based on case-control studies. Journal of Trace Elements in Medicine and Biology, 67, 126782.
  • Zong, W., Lu, X., Dong, G., Zhang, L., & Li, K. (2023). Molecular mechanisms of exercise intervention in alleviating the symptoms of autism spectrum disorder: Targeting the structural alterations of synapse. Frontiers in psychiatry, 14, 1096503.

Document Type

Publication order reference

Identifiers

Biblioteka Nauki
47529705

YADDA identifier

bwmeta1.element.ojs-doi-10_18276_cej_2024_2-04
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