Artificial skin composites

• Authors: Agata Ładniak
• Languages of publication: EN

Abstracts

EN

Skin injuries are a health problem and can lead to serious, significant deterioration in the quality of life and, consequently, even illness and disability. Therefore, after wounding, immediate regeneration of the tissue is necessary to avoid further complications and pathogenesis. Consequently, many wound healing strategies have been developed, leading to the progress in constructing of multifunctional tissue substitutes for the skin, biomembranes, scaffolds and intelligent dressings. The field of science focusing on the creation of the above-mentioned products is tissue engineering (TE). Its main goal is to find a system that is able to replace or be a model that perfectly mimics the form and function of the skin. Research carried out on such constructs is mainly based on the analysis of mechanical properties (porosity, elasticity), as well as the assessment of the impact of individual components on processes related to the formation of new tissue as cell proliferation and differentiation, proliferation, angiogenesis - through in vivo studies (using animal models: mice, New Zealand rabbits) and in vitro (most often using mouse fibroblasts - L929). Skin constructions may have potential applications as wound dressings or skin substitutes in cases of severe skin damage.

Keywords

EN

titanium dioxide,; chitosan; hyaluronic acid; skin substitutes

• Publisher: Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej
• Journal: Annales Universitatis Mariae Curie-Skłodowska, sectio AA – Chemia
• Year: 2018
• Volume: 73
• Issue: 1

Dates

published

2018

online

2019-11-06

Contributors

author

Agata Ładniak

References

• [1] R. Langer, J.P. Vacanti, Science, 260, 920-926, (1993).
• [2] Q.L. Loh, C. Choong, Tissue Engineering: Part B, 19, 485-502, (2013).
• [3] A. Pianco, F. Paladini, M. Pollini, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 107, 7-18, (2019).
• [4] B. Joseph, R. Augustine, N. Kalarikkal, S. Thomas, Materials Today Communications, 19, 319-335, (2019).
• [5] S.M. Ahsan, M. Thomas, K.K. Reddy, S.G. Sooraparaju, A. Asthana, I. Bhatnagar, International Journal of Biological Macromolecules, 110, 97-109, (2018).
• [6] M. Sheikholeslam, M. E. E. Wright, M. G. Jeschke, S. Amini-Nik, Advanced Healthcare Materials, 7, 1700897, (2018).
• [7] C. Zhu, D. Fun, Z. Duan, X. Li, Y. Li, S. Wang, Y. Yu, Journal of Materials Science, 53, 5909–5928, (2018).
• [8] C. Berce, M.S. Muresan, O. Soritau, B. Petrushev, L. Tefas, I. Rigo, G. Ungureanu, C. Catoi, A. Irimie, C. Tomuleasa, Colloids and Surfaces B, 163, 155-166, (2018).
• [9] F. Croisier, G. Atanas
• ova, Y. Poumay, C. Jérôme, Advanced Healthcare Materials, 3, 2032-2039, (2014).
• [10] R. Singla, S.M.S. Abidi, A.I. Dar, A. Acharya, Journal of Biomedical Materials Research – Part B, (2019), DOI: 10.1002/jbm.b.34327.
• [11] J. Liu, D.A. Sonshine, S. Shervani, R.H. Hurt. American Chemical Society Nano, 4, 6903–6913, (2010).
• [12] A.F. Oyarzun, A. Vidal, M. Concha, J. Morales, S. Orellana, V.I. Moreno, Current Pharmaceutical Design, 21, 4329–4341, (2015).
• [13] A. Wennerberg, V. Frojd, M. Olsson, U. Nannmark, L. Emanuelsson, P. Johansson, Y. Josefsson, I. Kangasniemi, T. Peltola, T. Tirri, Clinical Implant Dentistry and Related Research, 13, 184–196, (2011).
• [14] A. Khalid, H. Ullah, M. Ul-Islam, R. Khan, S. Khan, F. Ahmad, T. Khan, RSC Advances, 7, 47662–47668, (2017).
• [15] N. Devi, J. Dutta, International Journal of Biological Macromolecules, 104, 1897–1904, (2017).
• [16] D. Archana, B.K. Singh, J. Dutta, P.K. Dutta, Carbohydrate Polymers, 95, 530–539, (2013).
• [17] T. Wang, Y. Zheng, Y. Shen, Y. Shi, F. Li, C. Su, L. Zhao, Artificial Cells, Nanomedicine, and Biotechnology, 46, 138-149, (2017).
• [18] H. Ye, J. Cheng, K. Yu, International Journal of Biological Macromolecules, 121, 633–642, (2019).

Identifiers

DOI

10.17951/aa.2018.73.1.51-60