Synthesis, spectral correlation analysis and evaluation of biological activities of some substituted hydrazones

• Authors: Renganathan Vijayakumar , Rajamohan Senbagam , Murugan Rajarajan , Selvaraj Balaji , Venkatesan Manikandan , Ganesan Vanangamudi , Ganesamoorthy Thirunarayanan
• Languages of publication: EN

Abstracts

EN

Some novel substituted hydrazone derivatives of amino guanidine have been synthesized with different substituted benzaldehydes by condensation method. The synthesized hydrazones were characterized by their physical constants, UV, IR and NMR spectra. The spectral data have been correlated with Hammett substituent constants and Swain–Lupton parameters. From the result of statistical analysis, the effects of substituents on the spectral data have been predicted. The antimicrobial activities of these synthesized hydrazone compounds have been screened by Bauer-Kirby method using human pathogenic bacteria and fungal species. The antimicrobial activities of all synthesized hydrazone compounds have shown significant activity.

Keywords

EN

Hydrazones; UV; IR & NMR spectra; Correlation analysis; Antimicrobial activities

• Publisher: Wydawnictwo Uniwersytetu Marii Curie-Skłodowskiej
• Journal: Annales Universitatis Mariae Curie-Skłodowska, sectio AA – Chemia
• Year: 2015
• Volume: 70
• Issue: 2

Dates

published

2015

online

2016-02-15

Contributors

author

Renganathan Vijayakumar

author

Rajamohan Senbagam

author

Murugan Rajarajan

author

Selvaraj Balaji

author

Venkatesan Manikandan

author

Ganesan Vanangamudi

author

Ganesamoorthy Thirunarayanan

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Identifiers

DOI

10.17951/aa.2015.70.2.103