Znaczenie uwarunkowań genetycznych w dysfunkcjach układu hemostazy w cukrzycy - potencjalne czynniki ryzyka powikłań naczyniowych

• Authors: Cezary Watała , Magdalena Boncler , Marcin Różalski

Title variants

PL

Significance of genetic po lymorphisms in haemostatic dysfunctions in diabetes mellitus - potential risk factors of vascular complications

Abstracts

EN

The unambiguous determination of etiopathogenetic factors underlying the increased risk
of vascular disease in diabetic patients remains to be established. Evidence accumulated
hitherto points that such an increased risk might be a constellation of metabolic disorders
and genetic background. Thus, the impairments in coagulation and fibrinolysis, which are
believed to partly result from metabolic disorders encountered in diabetes, and genetic factors
might be compounding in predisposing a diabetic individual to develop the late diabetic
sequelae sooner. The role of the latter seems superior with respect to some dysfunctions in
haemostasis. Hence, the monitoring of the frequency and distribution of genetic polymorphisms
of selected haemostatic proteins might be promising in an attempt to define the reasons of
altered haemostatic imbalance in patients with diabetes mellitus. Based on such a knowledge
one could discriminate the groups of patients with high risk for the development of vascular
disease, in whom pharmacological strategy to attenuate haemostatic impairments would be
desirable.

• Publisher: Wydawnictwo Uniwersytetu Łódzkiego
• Journal: Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
• Year: 1999
• Volume: 14

Dates

published

1999

Contributors

author

Cezary Watała

author

Magdalena Boncler

author

Marcin Różalski

other

Akademia Medyczna w Łodzi

Identifiers

URI

http://hdl.handle.net/11089/15207