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Significance of genetic po lymorphisms in haemostatic dysfunctions in diabetes mellitus - potential risk factors of vascular complications
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Abstracts
The unambiguous determination of etiopathogenetic factors underlying the increased risk
of vascular disease in diabetic patients remains to be established. Evidence accumulated
hitherto points that such an increased risk might be a constellation of metabolic disorders
and genetic background. Thus, the impairments in coagulation and fibrinolysis, which are
believed to partly result from metabolic disorders encountered in diabetes, and genetic factors
might be compounding in predisposing a diabetic individual to develop the late diabetic
sequelae sooner. The role of the latter seems superior with respect to some dysfunctions in
haemostasis. Hence, the monitoring of the frequency and distribution of genetic polymorphisms
of selected haemostatic proteins might be promising in an attempt to define the reasons of
altered haemostatic imbalance in patients with diabetes mellitus. Based on such a knowledge
one could discriminate the groups of patients with high risk for the development of vascular
disease, in whom pharmacological strategy to attenuate haemostatic impairments would be
desirable.
of vascular disease in diabetic patients remains to be established. Evidence accumulated
hitherto points that such an increased risk might be a constellation of metabolic disorders
and genetic background. Thus, the impairments in coagulation and fibrinolysis, which are
believed to partly result from metabolic disorders encountered in diabetes, and genetic factors
might be compounding in predisposing a diabetic individual to develop the late diabetic
sequelae sooner. The role of the latter seems superior with respect to some dysfunctions in
haemostasis. Hence, the monitoring of the frequency and distribution of genetic polymorphisms
of selected haemostatic proteins might be promising in an attempt to define the reasons of
altered haemostatic imbalance in patients with diabetes mellitus. Based on such a knowledge
one could discriminate the groups of patients with high risk for the development of vascular
disease, in whom pharmacological strategy to attenuate haemostatic impairments would be
desirable.
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1999
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author
author
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Publication order reference
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http://hdl.handle.net/11089/15207
YADDA identifier
bwmeta1.element.hdl_11089_15207
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