Journal
Article title
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Full texts:
Title variants
Structure and function of epidermal growth factor receptor
Languages of publication
Abstracts
This review presents the contemporary knowledge on the epidermal growth factor receptor
(EGFR) structure and function, and participation in neoplastic transformation. The EGFR
has been implicated in the pathogenesis of multiple human cells and tissues. Altered levels of
the receptor have been found in, among others, breast, prostate, and colon carcinomas.
Usually, overexperssion of EGFR appears to confer a worse prognosis. Also some tumours
types expressed structurally altered EGFR with deletion in extracellular domain. The correlation
of EGFR expression with invasive or disseminated tumours and the connection with drug
insensitivity provide ready justification for therapeutic intervention aimed at modulating the
activity of this receptor.
(EGFR) structure and function, and participation in neoplastic transformation. The EGFR
has been implicated in the pathogenesis of multiple human cells and tissues. Altered levels of
the receptor have been found in, among others, breast, prostate, and colon carcinomas.
Usually, overexperssion of EGFR appears to confer a worse prognosis. Also some tumours
types expressed structurally altered EGFR with deletion in extracellular domain. The correlation
of EGFR expression with invasive or disseminated tumours and the connection with drug
insensitivity provide ready justification for therapeutic intervention aimed at modulating the
activity of this receptor.
Keywords
Publisher
Year
Volume
Physical description
Dates
published
1999
Contributors
author
author
author
References
Document Type
Publication order reference
Identifiers
URI
http://hdl.handle.net/11089/14956
YADDA identifier
bwmeta1.element.hdl_11089_14956
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