Struktura i funkcja receptora czynnika wzrostu naskórka

• Authors: Magdalena Bryś , Magdalena Nawrot , Wanda Krajewska

Title variants

PL

Structure and function of epidermal growth factor receptor

Abstracts

EN

This review presents the contemporary knowledge on the epidermal growth factor receptor
(EGFR) structure and function, and participation in neoplastic transformation. The EGFR
has been implicated in the pathogenesis of multiple human cells and tissues. Altered levels of
the receptor have been found in, among others, breast, prostate, and colon carcinomas.
Usually, overexperssion of EGFR appears to confer a worse prognosis. Also some tumours
types expressed structurally altered EGFR with deletion in extracellular domain. The correlation
of EGFR expression with invasive or disseminated tumours and the connection with drug
insensitivity provide ready justification for therapeutic intervention aimed at modulating the
activity of this receptor.

• Publisher: Wydawnictwo Uniwersytetu Łódzkiego
• Journal: Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
• Year: 1999
• Volume: 14

Dates

published

1999

Contributors

author

Magdalena Bryś

author

Magdalena Nawrot

author

Wanda Krajewska

other

Katedra Cytobiochemii Uniwersytet Łódzki

Identifiers

URI

http://hdl.handle.net/11089/14956