Zmiany poziomu glutationu i aktywności transferazy glutationowej w płytkach krwi indukowane związkami selenu

• Authors: Halina Żbikowska , Tadeusz Krajewski , Barbara Wachowicz

Title variants

PL

Selenium - induced changes of GSH level and glutathione S-transferase activity in blood platelets

Abstracts

EN

The effects of inorganic selenocompounds (sodium selenite and selenate) on the level of
reduced glutathione, free sulfhydryl groups of proteins and the activity of S-glutathione
transferase (GST) in pig blood platelets were studied. It was shown that selenite, contrary to
selenate reduced the amounts of both GSH and -SH of platelet proteins. The concentration
of GSH after one-hour treatment of platelets with a high dose of selenite (10-4 M) was
reduced by 50%. A decrease in protein thiols was also significant. We observed that the
activity of platelet GST was inhibited after incubation of these cells with a toxic dose of
selenite but not selenate.

• Publisher: Wydawnictwo Uniwersytetu Łódzkiego
• Journal: Acta Universitatis Lodziensis. Folia Biochimica et Biophysica
• Year: 1997
• Volume: 12

Dates

published

1997

Contributors

author

Halina Żbikowska

author

Tadeusz Krajewski

author

Barbara Wachowicz

other

Katedra Biochemii Ogólnej Uniwersytet Łódzki

Identifiers

URI

http://hdl.handle.net/11089/14474