The basic biology of erbB-2 and its participation in colorectal cancers

• Authors: Magdalena Stawińska , Magdalena Bryś , Wanda M Krajewska

Abstracts

EN

ErbB-2 is one of Tour cell surface growth factor receptors involved in transmission
of signals controlling normal cell growth and differentiation. A range of growth
factors serve as ligands, but none is specific for the ErbB-2 receptor. Ligand binding to
ErbB-1, ErbB-3 and ErbB-4 induces rapid receptor dimerization, with a marked preference
for ErbB-2 as a dimer partner. When ErbB-2 is overexpressed multiple ErbB-2 heterodimers
are formed and cell signalling is stronger, resulting in enhanced responsiveness to
growth factors and malignant growth. This explains why ErbB-2 overexpression is an
indicator of poor prognosis in colorectal cancers and may be predictive of response to
treatment. ErbB-2 is a highly specific and promising target for new colon cancer treatments.

Keywords

EN

ErbB-2; colorectal cancers; signal transduction; tumour growth

• Publisher: Wydawnictwo Uniwersytetu Łódzkiego
• Journal: Acta Universitatis Lodziensis. Folia Biologica et Oecologica
• Year: 2005
• Volume: 2

Dates

published

2005

Contributors

author

Magdalena Stawińska

author

Magdalena Bryś

author

Wanda M Krajewska

other

Department of Cytobiochemistry University of Łódź

other

zreg@biol uni lodz pl

Identifiers

URI

http://hdl.handle.net/11089/12099