Journal
Article title
Content
Full texts:
Title variants
Languages of publication
Abstracts
ErbB-2 is one of Tour cell surface growth factor receptors involved in transmission
of signals controlling normal cell growth and differentiation. A range of growth
factors serve as ligands, but none is specific for the ErbB-2 receptor. Ligand binding to
ErbB-1, ErbB-3 and ErbB-4 induces rapid receptor dimerization, with a marked preference
for ErbB-2 as a dimer partner. When ErbB-2 is overexpressed multiple ErbB-2 heterodimers
are formed and cell signalling is stronger, resulting in enhanced responsiveness to
growth factors and malignant growth. This explains why ErbB-2 overexpression is an
indicator of poor prognosis in colorectal cancers and may be predictive of response to
treatment. ErbB-2 is a highly specific and promising target for new colon cancer treatments.
of signals controlling normal cell growth and differentiation. A range of growth
factors serve as ligands, but none is specific for the ErbB-2 receptor. Ligand binding to
ErbB-1, ErbB-3 and ErbB-4 induces rapid receptor dimerization, with a marked preference
for ErbB-2 as a dimer partner. When ErbB-2 is overexpressed multiple ErbB-2 heterodimers
are formed and cell signalling is stronger, resulting in enhanced responsiveness to
growth factors and malignant growth. This explains why ErbB-2 overexpression is an
indicator of poor prognosis in colorectal cancers and may be predictive of response to
treatment. ErbB-2 is a highly specific and promising target for new colon cancer treatments.
Publisher
Year
Volume
Physical description
Dates
published
2005
Contributors
author
author
author
other
References
Document Type
Publication order reference
Identifiers
URI
http://hdl.handle.net/11089/12099
YADDA identifier
bwmeta1.element.hdl_11089_12099