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Title variants
Molecular mechanisms of signal transduction in selected receptor systems of blood platelets
Languages of publication
Abstracts
This review paper concerns molecular mechanisms of signal transduction by various
receptor systems and the role of various agonists in the activation of blood platelets. Authors
present the physiological pathways leading to platelet activation and release reaction, as well
as those responsible for the natural feedback inhibition of platelet activation. The significance
of the conformational changes in platelet receptor glycoproteins, the reorganisation of platelet
cytoskeleton, the mobilisation of calcium, processes of phosphorylation/déphosphorylation, and
lipid bilayer fluidity in the modulation of the triggering of platelet signal transduction is discussed.
receptor systems and the role of various agonists in the activation of blood platelets. Authors
present the physiological pathways leading to platelet activation and release reaction, as well
as those responsible for the natural feedback inhibition of platelet activation. The significance
of the conformational changes in platelet receptor glycoproteins, the reorganisation of platelet
cytoskeleton, the mobilisation of calcium, processes of phosphorylation/déphosphorylation, and
lipid bilayer fluidity in the modulation of the triggering of platelet signal transduction is discussed.
Keywords
Publisher
Year
Volume
Physical description
Dates
published
2001
Contributors
References
Document Type
Publication order reference
Identifiers
URI
http://hdl.handle.net/11089/12037
YADDA identifier
bwmeta1.element.hdl_11089_12037
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