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2001 | 15 |
Article title

Genotoxicity of the organophosphorus compound methylparaoxon evaluated by the comet assay

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Abstracts
EN
Pesticides are widely used in agriculture, food production and household. Due to the
broad spectrum of their activity, their biological action is extensively investigated. We
assessed the genotoxidty of methylparaoxon - the main metabolite of commonly used
organophosphorus insecticide, methylparathion. Freshly isolated human peripheral blood
lymphocytes were incubated for 1 h with methylparaoxon at 37° C, and then, were
incubated in methylparaoxon-free medium to examine DNA repair. Alkaline single cell
gel electrophoresis (the comet assay) was used to assess DNA damage and repair.
Methylparaoxon induced moderate DNA damages that were almost completely repaired
after 60 min. Obtained results suggest that methylparaoxon could induce single-strand
breaks in DNA both directly and by methylathion of DNA bases.
Keywords
Year
Volume
15
Physical description
Dates
published
2001
References
Document Type
Publication order reference
Identifiers
URI
http://hdl.handle.net/11089/12035
YADDA identifier
bwmeta1.element.hdl_11089_12035
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