Selective inhibitors of cyclooxygenase-2 (COX-2)
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Cyclooxygenase is key enzyme in the prostaglandin synthesis. It exists in two isoforms, which have distinct roles in the organism. Cyclooxygenase-2 (COX-2) participates in the pathophysiology of inflammation. Differences in the molecular structure of cyclooxygenases allowed to develop drug that selectively inhibit that isoform. Recently, selective inhibitors of COX-2 were introduced into therapy, providing new opportunities to the treatment of inflammation.
Publication order reference
F. Mejza, Klinika Pulmonologii, II Katedra Chorob Wewnetrznych CM UJ, ul. Skawinska 8, 31-066 Krakow, Poland