The role of hepatocyte growth factor/c-met interactions in the immune system (p. )
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Hepatocyte growth factor (HGF) is a pleiotropic cytokine with mitogenic, motogenic and morphogenic activity for mainly epithelial and endothelial target cells. All the different effects of HGF are mediated through its specific receptor met, a heterodimeric transmembrane tyrosine kinase. The broad activity of HGF and its impact on many physiologic and pathologic processes are reflected by met expression in a variety of organs and cell types. This paper discusses expression of HGF and c-met within the immune system and their interactions in the control of immune cell functions.
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G. Skibinski, Respiratory Research Group, Department of Clinical Biochemistry, Institute of Clinical Science, Queen?s University of Belfast, Belfast BT12 6BJ, Northern Ireland, UK