Immunotherapy of type 1 diabetes

• Authors: L. Li , Z. Yi , R. Tisch , B. Wang
• Languages of publication: EN

Abstracts

EN

Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing beta cells are destroyed. Diabetic patients manage their hyperglycemia by daily insulin injections. However, insulin therapy is by no means a cure. Accordingly, a significant effort has been ongoing to develop immunotherapies that effectively prevent and/or treat T1D in the clinic. This review focuses on antigen- and antibody-based immunotherapies and discusses the respective strengths and weaknesses of these approaches.

Keywords

EN

ANTIBODY; ANTIGEN; IMMUNOREGULATORY; T CELL; TOLERANCE

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2008
• Volume: 56
• Issue: 4
• Pages: 227-236

Contributors

author

L. Li

author

Z. Yi

author

R. Tisch

author

B. Wang

• Document Type: REVIEW
• Publication order reference: Roland Tisch, Department of Microbiology and Immunology, Mary Ellen Jones Bldg., Room 635, Campus Box 7290, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7290, USA