Effects of pituitary adenylate cyclase-activating polypeptide (PACAP) on cyclic AMP formation in the duck and goose brain

• Authors: J. Z. Nowak , K. Kuba , J.B. Zawilska
• Languages of publication: EN

Abstracts

EN

Two molecular forms of pituitary adenylate cyclase-activating polypeptide (PACAP), i.e., PACAP27 and PACAP38 (0.0001-1 muM), as well as vasoactive intestinal polypeptide (VIP; 0.1-3 muM), have been studied for their effects on cyclic AMP formation in the hypothalamus and cerebral cortex of duck and goose. All three peptides concentration-dependently stimulated cyclic AMP production in the tested brain regions of 2-3-weeks-old (young) ducks, with VIP showing at least one order of magnitude weaker activity than PACAP. This characteristics suggests the existence in the duck's brain of adenylyl cyclase-linked PAC1 receptors. Both forms of PACAP also stimulated the nucleotide formation in the cerebral cortex and hypothalamus of 5-6-months-old (adult) ducks or geese grown under natural environment. The peptides-evoked effects in adult and young ducks were comparable, and clearly greater than those found in adult geese. The present data extend our recent observations made on chicks, and suggest PACAP to be a potent stimulator of the cyclic AMP generation in the avian central nervous system.

Keywords

EN

CEREBRAL CORTEX; CYCLIC AMP; DUCK; GOOSE; HYPOTHALAMUS; VASOACTIVE INTESTINAL POLYPEPTIDE

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2000
• Volume: 60
• Issue: 2
• Pages: 209-214

Contributors

author

J. Z. Nowak

author

K. Kuba

author

J.B. Zawilska

• Document Type: communication
• Publication order reference: J. Z. Nowak, Department of Biogenic Amines, Polish Academy of Sciences, 3 Tylna St., P-225, 90-950 Lodz, Poland, Email: [e-mail]