PL EN


Preferences help
enabled [disable] Abstract
Number of results
2007 | 55 | 1 | 27-34
Article title

Transcriptional regulation in thymic epithelial cells for the establishment of self tolerance

Authors
Title variants
Languages of publication
EN
Abstracts
EN
Thymic epithelial cells (TECs) play pivotal roles in the establishment of self tolerance through critical dialogue with developing thymocytes. Unique actions of two transcriptional regulators within TECs, NF-kB-inducing kinase (NIK) and an autoimmune regulator (AIRE), for the establishment of self tolerance have recently been highlighted by studies using a strain of mouse bearing a natural mutation of the NIK gene (aly mice) and gene-targeted mice, respectively. Previous studies have demonstrated essential roles of NIK downstream of the lymphotoxin-beta receptor (LTbetaR), which is essential for the development of secondary lymphoid organs; aly mice lack all lymph nodes and Peyer's patches because of the defective LTbetaR signaling. Additional roles of NIK in thymic organogenesis downstream of LTbetaR, mainly through the developmental regulation of TECs, have now emerged, although the corresponding ligand(s) for LTbetaR participating in this action have not been fully characterized. In contrast, AIRE, a gene responsible for the development of an organ-specific autoimmune disease that demonstrates monogenic autosomal recessive inheritance, contributes to the establishment of self tolerance probably by controlling the expression of self antigens through yet undetermined molecular mechanisms. Thus it is highly likely that a group of genes control self-tolerance within TECs through unique and coordinated actions, and that an understanding of this process would help to unravel the pathogenesis of autoimmune disease.
Publisher

Year
Volume
55
Issue
1
Pages
27-34
Physical description
Contributors
author
References
Document Type
REVIEW
Publication order reference
Mitsuru Matsumoto, M.D. Ph.D., Division of Molecular Immunology, Institute for Enzyme Research, University of Tokushima, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-faf7d48e-873b-3b96-81e8-7ef231189ab1
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.