Idiopathic pulmonary fibrosis: molecular mechanisms and possible therapeutic strategies

• Authors: den_ Blink B. Van_ , H.M. Jansen , M.P. Peppelenbosch
• Languages of publication: EN

Abstracts

EN

Idiopathic pulmonary fibrosis (IPF) is a devastating disease with an almost universally terminal outcome. In recent years much insight has been gained into the pathogenesis of IPF from both a bleomycin mice-model as well as ex vivo human tissue studies. Alveolar damage and inflammation of unknown etiology, eventually leading to interstitial fibrosis, characterize IPF. Apoptosis has emerged as an important factor in the pathogenesis of IPF. This review will outline the current understanding of the immunological and molecular mechanisms underlying IPF, and discuss new therapeutic strategies.

Keywords

EN

APOPTOSIS; BLEOMYCIN; FAS; FIBROSIS; INFLAMMATION

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2000
• Volume: 48
• Issue: 5
• Pages: 539-546

Contributors

author

den_ Blink B. Van_

author

H.M. Jansen

author

M.P. Peppelenbosch

• Document Type: REVIEW
• Publication order reference: B. Van den Blink, Laboratory of Experimental Internal Medicine, Academic Medical Center, G2-130, Meibergdreef 9, NL-1105 AZ Amsterdam, The Netherlands