Viral infections in xenotransplantation and their detection strategies

• Authors: U. Mazurek , G. Janikowska , Z. Wydmuch , T. Wilczok
• Languages of publication: PL

Abstracts

EN

Utilizing animals as organ donors for humans may cause transmission of foreign species pathogens to the recipient. To minimize the risk of transmission of infectious diseases from animals to humans, the strategy of appropriate animal selection is being assessed. The aim of the selection of specific pathogen-free pigs was the differentiation of active viruses from latent ones in both the recipients and donors in search of the host gene expression profiles which would differentiate the beginning of transplant rejection from an active infection. Additionally, the researchers searched for gene profile expressions indicating the type of infection which would considerably reduce the time of detection, and the cause of disease in the recipient which would offer a better chance of a positive result of the surgery.

Keywords

EN

GENE EXPRESSION; RT-PCR; VIRAL INFECTION; XENOTRANSPLANTATION

Discipline

• BIOTECHNOLOGY: BIOTECHNOLOGY

• Publisher: Committee of Biotechnology, Polish Academy of Sciences
• Journal: Biotechnologia
• Year: 2006
• Issue: 1
• Pages: 125-132

Contributors

author

U. Mazurek

author

G. Janikowska

author

Z. Wydmuch

author

T. Wilczok

• Document Type: REVIEW
• Publication order reference: Urszula Mazurek, Katedra Biologii Molekularnej i Genetyki Medycznej, ul. Ostrogorska 30, 41-200 Sosnowiec, Poland