The biological activity of synthetic analogs of the laminin active sequences: YIGSR, RGD, SIKVAV

• Authors: A. Hill-Bator , A. Opolski
• Languages of publication: PL

Abstracts

EN

The invasion of malignant cells through the basement membrane is a critical step in local infiltration and metastasis. Adhesion and invasion of malignant cells may be modulated by their receptor mediated binding to the basement membrane glycoprotein laminin. Laminin consists of the sequences with anticancer and antimetastatic activity. Its peptide fragment YIGSR is known to inhibit experimental metastases of several tumors. This sequence and a tripeptide RGD of laminin inhibits both angiogenesis and tumor growth. In contrary, the sequence SIKVAV initiates angiogenesis and tumor progression. Moreover, laminin plays also other functions in human organism. One of them is influence on platelet aggregation and trombegenesis.

Keywords

EN

ANALOG; BIOLOGICAL ACTIVITY; LAMININ

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Index Copernicus International
• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 2002
• Volume: 56
• Issue: 5
• Pages: 579-588

Contributors

author

A. Hill-Bator

author

A. Opolski

• Document Type: ARTICLE
• Publication order reference: A. Hill-Bator, Instytut Immunologii i Terapii Doswiadczalnej PAN, ul. R.Weigla 12, 53-114 Wroclaw, Poland