Surfactant proteins SP-A and SP-D in human health and dis

• Authors: U. Kishore , Bernal A. Lopez , M.F. Kamran , S. Saxena , M. Singh , P.U. Sarma , T. Madan , T. Chakraborty
• Languages of publication: EN

Abstracts

EN

Surfactant proteins A (SP-A) and D (SP-D) are lung surfactant-associated hydrophilic proteins which have been implicated in surfactant homeostasis and pulmonary innate immunity. They are collagen-containing C-type (calcium-dependent) lectins, called collectins, and are structurally similar to mannose-binding protein of the lectin pathway of the complement system. Being carbohydrate pattern-recognition molecules, they recognize a broad spectrum of pathogens and allergens via the lectin domain, with subsequent activation of immune cells via the collagen region, thus offering protection against infection and allergenic challenge. SP-A and SP-D have been shown to be involved in viral neutralization, clearance of bacteria, fungi, and apoptotic and necrotic cells, the down-regulation of allergic reaction, and the resolution of inflammation. Studies on single-nucleotide polymorphism, protein levels in broncho-alveolar lavage, and gene knock-out mice have clearly indicated an association between SP-A and SP-D and a range of pulmonary diseases. In addition, recent studies using murine models of allergy and infection have raised the possibility that the recombinant forms of SP-A and SP-D may have therapeutic potential in controlling pulmonary infection, inflammation, and allergies in humans.

Keywords

EN

ALLERGY; DISEASE; IMMUNITY; LUNG; PATHOGEN; PREGNANCY

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2005
• Volume: 53
• Issue: 5
• Pages: 399-417

Contributors

author

U. Kishore

author

Bernal A. Lopez

author

M.F. Kamran

author

S. Saxena

author

M. Singh

author

P.U. Sarma

author

T. Madan

author

T. Chakraborty

• Document Type: REVIEW
• Publication order reference: Uday Kishore, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK