Expression of Angiopoietin-1 and the receptor Tie-2 mRNA in rat brains following intracerebral hemorrhage

• Authors: H.J. Zhou , T. Tang , C. Guo , H.N. Zhang , J.H. Zhong , J. Zheng , J.K. Luo , Y. Lin , W. Liu , W.F. Luo , Q.D. Yang
• Languages of publication: EN

Abstracts

EN

Angiopoietin-1 (Ang-1) belongs to a novel family of endothelial growth factors that function as ligands for an endothelialspecific receptor tyrosine kinase (Tie-2). The Ang-1/Tie-2 system may contribute to angiogenesis and vascular remodeling by mediating interactions of endothelial cells with smooth muscle cells and pericytes. The spatial distribution and temporal expression of Ang-1 and Tie-2 in the rat brain were studied following collagenase-induced intracerebral hemorrhage (ICH), by immunohistochemistry and reverse transcription-polymerase chain (RT-PCR) analysis, respectively. Immunohistochemical analysis revealed that some Ang-1 or Tie-2-positive dilated vessels resided around the hematoma and extended into the clot. RT-PCR analysis showed that Ang-1 and Tie-2 mRNA signal was detected at 2 days and persisted for 28 days after ICH. These findings suggest that ICH could lead to upregulation of Ang-1 and the receptor Tie-2 mRNA.

Keywords

EN

ANGIOGENESIS; ANGIOPOIETIN-1; HEMORRHAGE; RECEPTOR

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2008
• Volume: 68
• Issue: 2
• Pages: 147-154

Contributors

author

H.J. Zhou

author

T. Tang

author

C. Guo

author

H.N. Zhang

author

J.H. Zhong

author

J. Zheng

author

J.K. Luo

author

Y. Lin

author

W. Liu

author

W.F. Luo

author

Q.D. Yang

• Document Type: ARTICLE
• Publication order reference: T. Tang, Institute of Integrative Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, PR China