PL EN


Preferences help
enabled [disable] Abstract
Number of results
2005 | 53 | 6 | 497-504
Article title

Roles of galectin-3 in immune responses

Content
Title variants
Languages of publication
EN
Abstracts
EN
Galectins are a family of animal lectins with conserved carbohydrate-recognition domains for b-galactoside. Galectin-3 is the only family member that is composed of a glycine/proline-rich N-terminal repeated sequence and a C-terminal carbohydrate-binding domain. Multiple functions of galectin-3 have been reported, depending on its location. Extracelluar galectin-3 can bind to cell surface through glycosylated proteins and thereby trigger or modulate cellular responses such as mediator release or apoptosis. Intracellular galectin-3 has been reported to inhibit apoptosis, regulate the cell cycle, and participate in the nuclear splicing of pre-mRNA. Recent studies have revealed that galectin-3 is expressed in a variety of cell types in the immune system, constitutively or in response to microbial invasion. These studies implicate galectin-3 in both innate and adaptive immune responses, where it participates in the activation or differentiation of immune cells. This review summarizes the roles of galectin-3 in the immune system and discusses the possible underlying mechanisms.
Keywords
References
Document Type
REVIEW
Publication order reference
Huan Yuan Chen, University of California, Davis, School of Medicine, Sacramento, CA 96817, USA
YADDA identifier
bwmeta1.element.element-from-psjc-f62fed58-3fc3-3eb0-a830-b981c26b0725
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.